MATERIALS AND METHODS < A systematic search was conducted of the relevant published evidence from Embase, MEDLINE, and Cochrane < Search limits were articles in English and human < Retrieved citations were screened by two independent reviewers according to inclusion criteria: < Population: NMO patients with any age Interventions: Any interventions for treatment for NMO < Outcomes: Incidence and...

S. Bará Area de Optica, E.U., Optica e Optometria, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, GALIZA Spain A. Ciro López Grupo de Optica y Fotonica, Instituto de Fisica, Universidad de Antioquia, A.A1226, Medellin, Colombia Facultad de Ciencias, Instituto Tecnologico Metropolitano, calle 73 #76A-354, Medellin, Colombia Z. Jaroszewicz [email protected] Institute ...

Objective To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT). Methods This is a retrospective, descriptive and analytic study. Results Among NMO patients, there was a predominance of women, with onset in the fou...

Karpakam, a female Hindu child of 7 years, was admitted into the Madras General Hospital, under Lieut.-Colonel McRobert, i.m.s., on the 23rd November, 1939. The complaint was blindness and inability to use the lower limbs. There had been no previous illnesses of note, the family history was negative and the dietary habits similar to those of her class, i.e., non-vegetarian. The child had been a...

We used two methods to estimate short-wave (S) cone spectral sensitivity. Firstly, we measured S-cone thresholds centrally and peripherally in five trichromats, and in three blue-cone monochromats, who lack functioning middle-wave (M) and long-wave (L) cones. Secondly, we analyzed standard color-matching data. Both methods yielded equivalent results, on the basis of which we propose new S-cone ...

Neuromyelitis optica (NMO) is an idiopathic inflammatory disorder of the central nervous system (CNS) that preferentially affects the optic nerves and spinal cord. In Asia, NMO has long been considered a subtype of multiple sclerosis (MS). However, recent clinical, pathological, immunological, and imaging studies have suggested that NMO is distinct from MS. This reconsideration of NMO was initi...

Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4). These autoantibodies are predominantly IgG1, and considerable evidence supports their pathogenicity, presumably by ...

Background A specific humoral immune response against HERV-W envelope surface (env-su) glycoprotein antigens has been reported in serum of patients with multiple sclerosis (MS). However, it has not been evaluated to date in patients with neuromyelitis optica spectrum disorder (NMOSD). Objective The objective of this paper is to investigate whether antibody (Ab) response against HERV-W env-su ...

BACKGROUND AND PURPOSE Acute myelitis patients exhibiting only sensory deficits upon initial presentation are not commonly encountered in clinical practice, but they definitely exist. Since acute sensory myelitis has not been investigated previously, this study evaluated the etiological spectrum of the condition with the aim of describing the clinical characteristics thereof. METHODS Patients...

Tacrolimus, a novel immunosuppressant agent, has been widely used in organ transplantation and autoimmune diseases. We herein present a case of neuromyelitis optica spectrum disorder (NMOSD) combined with Sjögren's syndrome (SS) successfully treated with tacrolimus. This patient repeatedly presented with recurrent longitudinally extensive transverse myelitis. Her NMO-IgG and anti-SSA and anti-S...