The autosomal recessive neuromuscular disease spinal muscular atrophy (SMA) is caused by loss of survival motor neuron (SMN) protein. Molecular pathways that are disrupted downstream of SMN therefore represent potentially attractive therapeutic targets for SMA. Here, we demonstrate that therapeutic targeting of ubiquitin pathways disrupted as a consequence of SMN depletion, by increasing levels...

Running economy (RE) is considered an important physiological measure for endurance athletes, especially distance runners. This review considers 1) how RE is defined and measured and 2) physiological and biomechanical factors that determine or influence RE. It is difficult to accurately ascertain what is good, average, and poor RE between athletes and studies due to variation in protocols, gas-...

T he article by McLean et al.2 builds on a burgeoning body of literature that for more than 50 yr has described potential complications associated with the use of neuromuscular-blocking agents (NMBAs). There seem to be two themes: The first irrefutable finding is affirmation that the use of NMBAs is associated with postoperative residual weakness that may lead to significant morbidity and, rare...

This study examined whether home-based, high-speed calf-raise training changes the rate of torque development (RTD) during plantar flexion contractions and balance performance in elderly men. Thirty-four healthy elderly men (73 ± 5 yr) were randomly assigned to a training or control group (n = 17 in each group). The subjects in the training group completed 8 wk (3 times/wk) of home-based bilate...

PURPOSE Heavy-resistance training and plyometric training offer distinct physiological and neuromuscular adaptations that could enhance running economy and, consequently, distance-running performance. To date, no studies have examined the effect of combining the two modes of training on running economy or performance. METHODS Fifty collegiate male and female cross-country runners performed a ...

to compare intubating conditions and hemodynamic changes between bonfils intubation fiberscope and macintosh laryngoscopy without administering neuromuscular blocking drugs (nmbds). methods: in this randomized controlled trial,80 male and female patients, scheduled for elective surgery, aged 15 to 60 years, asa class ii or i, non-obese, non smokers, without anticipated difficult intubation; wer...

Ahmed, T. (2015). Improving musculoskeletal fitness and the performance enhancement of basketball skills through neuromuscular training program. J. Hum. Sport Exerc., 10(3), pp.795-804. The purpose of this study was to evaluate the effect of eight weeks of neuromuscular training program (NMTP) on musculoskeletal fitness and performance enhancement for basketball players. Twenty four male basket...

PURPOSE To investigate the time course of recovery from neuromuscular fatigue and some biochemical changes between two female soccer matches separated by an active or passive recovery regime. METHODS Countermovement jump (CMJ), sprint performance, maximal isokinetic knee flexion and extension, creatine kinase (CK), urea, uric acid, and perceived muscle soreness were measured in 17 elite femal...

conclusions according to the findings of the current study, both open-loop and closed-loop neuromuscular control mechanisms altered in patients with cai. methods it was a case-control study. twenty-two subjects with unilateral cai and 22 healthy subjects stood on a force plate and initiated gait with maximal velocity under 2 conditions: i) planned (initiated gait after hearing the “all set” sig...

One objective of this study was to investigate whether neuromuscular quantities were associated with preferred pedaling rate selection during submaximal steady-state cycling from a theoretical perspective using a musculoskeletal model with an optimal control analysis. Specific neuromuscular quantities of interest were the individual muscle activation, force, stress and endurance. To achieve thi...