نتایج جستجو برای: neuromedin s

تعداد نتایج: 711493  

Journal: :Clinical chemistry 1993
P H Gamache M L Kingery I N Acworth

We describe a procedure for the direct measurement of metanephrine (MN) and normetanephrine (NMN) in hydrolyzed urine, using HPLC with coulometric array detection. Acid-hydrolyzed samples were diluted and filtered before separation by isocratic reversed-phase ion-pair chromatography. Eight serial coulometric sensors, set at incrementally increasing anodic potentials, were used to screen lower-o...

Journal: :Journal of neuroendocrinology 2006
C M Novak M Zhang J A Levine

Brain neuromedin U (NMU) has been associated with the regulation of both energy intake and expenditure. We hypothesized that NMU induces changes in spontaneous physical activity and nonexercise activity thermogenesis (NEAT) through its actions on hypothalamic nuclei. We applied increasing doses of NMU directly to the paraventricular (PVN) and arcuate hypothalamic nuclei using chronic unilateral...

Journal: :CJEM 2010
Rhonda J Rosychuk Donald C Voaklander Terry P Klassen Ambikaipakan Senthilselvan Thomas J Marrie Brian H Rowe

OBJECTIVE We describe the epidemiology of asthma presentations to emergency departments (EDs) for 3 main regions in the province of Alberta. METHODS We used a comprehensive ED database to identify ED visits in Alberta from April 1999 to March 2005. We linked the visits to other provincial administrative databases to obtain all data on follow-up encounters for asthma during that period. Inform...

2010
Nigel M Page

At the start of the last decade, we provided evidence that levels of the peptide neurokinin B were highly elevated in pre-eclampsia. We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms. At the time of the original hypothesis many questions remained outs...

Journal: :The Journal of biological chemistry 1991
M H Corjay D J Dobrzanski J M Way J Viallet H Shapira P Worland E A Sausville J F Battey

Bombesin-like peptides have been implicated as autocrine growth factors influencing the pathogenesis and progression of some human lung carcinoma cells. To determine the pharmacologic and structural properties of the bombesin receptors expressed in human lung carcinoma cells, cDNA clones encoding a human gastrin-releasing peptide receptor (GRP-R) and a pharmacologically distinct neuromedin-B pr...

Journal: :Neuron 2016
Cindy N. Chiu Jason Rihel Daniel A. Lee Chanpreet Singh Eric A. Mosser Shijia Chen Viveca Sapin Uyen Pham Jae Engle Brett J. Niles Christin J. Montz Sridhara Chakravarthy Steven Zimmerman Kourosh Salehi-Ashtiani Marc Vidal Alexander F. Schier David A. Prober

Neuromodulation of arousal states ensures that an animal appropriately responds to its environment and engages in behaviors necessary for survival. However, the molecular and circuit properties underlying neuromodulation of arousal states such as sleep and wakefulness remain unclear. To tackle this challenge in a systematic and unbiased manner, we performed a genetic overexpression screen to id...

2017
Jonghyeob Lee Emily R. Snyder Yinghua Liu Xueying Gu Jing Wang Brittany M. Flowers Yoo Jung Kim Sangbin Park Gregory L. Szot Ralph H. Hruban Teri A. Longacre Seung K. Kim

Development of systems that reconstitute hallmark features of human pancreatic intraepithelial neoplasia (PanINs), the precursor to pancreatic ductal adenocarcinoma, could generate new strategies for early diagnosis and intervention. However, human cell-based PanIN models with defined mutations are unavailable. Here, we report that genetic modification of primary human pancreatic cells leads to...

2016
Koji Ishiguro Rie Kurata Yoshikazu Shimada Yoto Sameshima Takashi Kume

Sweetpotato peptide (SPP) was prepared by enzyme digestion of sweetpotato protein from starch wastewater. Animal experiments assessed the effect of SPP on body weight, abdominal adipose tissue mass, serum lipids and adipocytokines. Body and liver weight and epididymal and mesenteric fat of mice fed a high-fat diet containing 0.5% or 5% SPP for 28 days were significantly lower than control mice....

Journal: :The International journal of developmental biology 2005
Hiroko Ohki-Hamazaki Maiko Iwabuchi Fumihiko Maekawa

Amphibian bombesin and its related peptides consist a family of neuropeptides in many vertebrate species. Bombesin and two major bombesin-like peptide in mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various physiological effects. These include inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, bloo...

Journal: :FEBS letters 2010
Man-Yeon Choi Russell A Jurenka

Pheromone biosynthesis-activating neuropeptide (PBAN) and pyrokinins belong to a family of insect peptide hormones that have a common FXPRLamide C-terminal ending. The G-protein-coupled receptors (GPCRs) for this peptide family were first identified from a moth and Drosophila with sequence similarity to neuromedin U receptors from vertebrates. We have characterized the PBAN-receptor (PBAN-R or ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید