BACKGROUND It is unclear to what extent the traditional distinction between neurological and psychiatric disorders reflects biological differences. AIMS To examine neuroimaging evidence for the distinction between neurological and psychiatric disorders. METHOD We performed an activation likelihood estimation meta-analysis on voxel-based morphometry studies reporting decreased grey matter in...

BACKGROUND Although gait disorders are common in the elderly, the prevalence and overall burden of these disorders in the general community is not well defined. METHODS In a cross-sectional investigation of the population-based Bruneck Study cohort, 488 community-residing elderly aged 60-97 years underwent a thorough neurological assessment including a standardized gait evaluation. Gait disor...

Malnutrition and weight loss, due to suboptimal oral intake, are common in patients with neurological disorders and are associated with increased morbidity, disability and mortality. The nutritional management of neurological patients is crucial, and enteral feeding is commonly used to provide nutritional support. This review presents the different methods of enteral tube feeding and discusses ...

'One picture is worth more than a thousand words'. A medical artist should always consider an illustration with this in mind. Unlike the brilliant illustrators of Dickens's novels, who needed to portray larger than life characters, a medical illustrator has to portray small, often complex structures, which may never be seen in the way it is illustrated, something a photograph could never achiev...

Patients with essential thrombocythemia often complain of various subjective neurological symptoms. This prospective study aims to assess their incidence and response to therapy. Among 37 consecutive patients with essential thrombocythemia, 11 presented with neurological symptoms. Among them 4 had thrombotic events, 7 complained of transient or fluctuating subjective symptoms, and one had both....

Alfred Christiaan SCHOUTEN werktuigkundig ingenieur geboren te Dordrecht, Nederland. Het onderzoek beschreven in dit proefschrift is mede mogelijk gemaakt door financiële on-dersteuning van de Nederlandse organisatie voor wetenschappelijk onderzoek, medische wetenschappen (NWO-MW, project nummer: 902-36-084). De pols manipulator beschreven in dit proefschrift is mede mogelijk gemaakt door een g...

Vascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of the choroid plexus endothelia, evokes edema, and activates the inflammatory pathway. Recently, w...