Introduction: Several studies have indicated that late treatment of aminoguanidine (AG) reduces cerebral ischemic injuries in animal models. However, the effects of early treatment of AG on cerebral ischemic damage are not well understood. This study was designed to evaluate effect of early treatment of AG on cortex and striatum injuries as well as neurological dysfunctions in transient mode...

introduction spontaneous spinal epidural hematoma (sseh) is an uncommon but potentially fatal condition. the increased bleeding tendency associated with anticoagulant medications has been proven to increase the risk of sseh. the symptoms of sseh usually begin with sudden severe neck or back pain and are followed by neurological deficits. however, some cases present with only axial pain or with ...

-

BACKGROUND AND PURPOSE We sought to define determinants of neurological deficit after surgery for brain arteriovenous malformation (AVM). METHODS One hundred twenty-four prospective patients (48% women, mean age 33 years) underwent microsurgical brain AVM resection. Patients were examined by 3 study neurologists immediately before surgery, postoperatively in-hospital, by in-person long-term f...

In the pre-MR era syringomyelia often presented late, as a crippling neurological disorder. Today, most cases are diagnosed earlier, with less pronounced deficits. We therefore new challenges, including understanding significance of various presenting symptoms, knowing when surgery might help and being aware other treatments that could benefit someone living effects syringomyelia, or its underl...

conclusions clinicians should be aware that tbm might have unusual presentations. early diagnosis and treatment are essential to decrease mortality and morbidity such as irreversible neurological deficits. case presentation a 66-year-old diabetic man was admitted to our hospital. he complained of prolonged left otalgia and headache. antibiotic therapy was started for mastoiditis and otitis medi...

biotin is a water-soluble vitamin and co-factor for activation of carboxylases apoenzymes. biotinidase enzyme is essential for release of biotin from apoenzymes. absence of biotinidase is an autosomal recessive trait with a prevalence of 1 in 60000. clinical manifestations of biotinidase deficiency include dermatitis, alopecia, seizures, hypotonia, developmental delay, hearing loss, visual impa...

BACKGROUND AND PURPOSE Neurological deficits and pain are common after displaced sacral fractures. However, little is known about the association between the long-term clinical outcomes and radiological findings. We examined the long-term radiological findings and their correlations with lumbosacral pain and neurological deficits in the lower extremities after surgery for sacral fractures. ME...

Clival chordomas are frequently midline structures. Due to their critical location, invasive nature and aggressive recurrences, skull base chordomas are difficult to manage surgically. We present a case operated on with the pedicled transnasal and transfacial approach. The case presented with neurological deficits as cranial nerve palsy and findings of brainstem compression. The lesion was remo...