1. Carcinomatous meningitis (metastases caused by carcinoma such as lung and breast) 2. Meningeal gliomatosis (dissemination of CSF caused by malignant glial tumors) 3. Leptomeningeal metastases secondary to other underlying solid tumors (e.g., rhabdomyosarcoma, neuroblastoma, medulloblastoma, other primitive neuroectodermal tumors) 4. Lymphomatous meningitis (metastases caused by lymphoma) 5. ...

The Ewing sarcoma family of tumors (ESFT) encompasses a group of highly aggressive, morphologically similar, malignant neoplasms sharing a common spontaneous genetic translocation that affect mostly children and young adults. These predominantly characteristic, small round-cell tumors include Ewing's sarcoma of the bone and soft tissue, as well as primitive neuroectodermal tumors (PNETs) involv...

Malignant gastrointestinal neuroectodermal tumor (GNET) is an infrequent soft-tissue sarcoma, formerly referred to as clear-cell sarcoma-like (CCSLGT) and frequently reported in the literature sarcoma of tract (CCS-GI); it characterized by absence melanocytic differentiation presence nontumoral osteoclast-like giant cells (OLGCs). The current study reports a case 79 year old woman admitted emer...

Melanotic neuro-ectodermal tumor of infancy is very rare. A unique neoplasm of the formative years, it typically involves the face or cranium; possesses rapid, expansile growth; presents as a firm swelling and displays a high rate of recurrence. Its rarity and unique features make diagnosis and management quite challenging. This challenge is increased in resource-limited settings like ours and ...

We describe herein a rare case of a primary primitive neuroectodermal tumor (PNET) in the mediastinum of a 75-year-old man. Grossly, the tumor was located in the left upper anterior mediastinum. Transcutaneous fine-needle biopsy (TCNB) revealed small round-cell proliferation. The expression immunohistochemical analysis was confirmed the diagnosis of PNET. He was successfully treated with chemot...