Anvirzel is an extract of Nerium oleander currently undergoing Phase I clinical evaluation as a potential treatment for cancer. Two of the active components of Anvirzel are the cardiac glycosides oleandrin and oleandrigenin. Previous studies have demonstrated that, in vitro, cardiac glycosides may inhibit fibroblast growth factor-2 (FGF-2) export through membrane interaction with the Na,K-ATPas...

Endophytic fungi found inside the plant tissue are endosymbionts, protecting their host from pests, pathogens, etc. Twenty eight endophytic fungi were isolated from different parts of Nerium oleander L., out of which, 54% of isolates were from flower, 39% from stem and 7% from leaf parts. Thirty six percent of the isolates showed antimicrobial activity against tested pathogens. The potential is...

dried oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to fivenative female goats. clinical signs of toxicosis in goats began to appear about 1 hr after receiving theoleander and included abdominal pain, ruminal atony and tympany, frequent urination, bradycardia,tachycardia, tachyarrhythmia, depression, weakness and convulsive movement and death at the end...