BACKGROUND Hikui disease is a well known disfiguring disease of koi carp (Cyprinus carpio) primarily affecting fish with red pigmentation. It causes light orange to golden yellow, multifocal to coalescing raised patches, starting from the red cutaneous areas. Some cases respond to surgery or topical treatment, but recurrence is common. OBJECTIVES To describe the clinical and pathological pres...

Many lines of evidence indicate that neoplastic transformation of cells occurs by a multistep process. For neoplastic transformation of normal human cells, they must be first immortalized and then be converted into neoplastic cells. It is well known that the immortalization is a critical step for the neoplastic transformation of cells and that the immortal phenotype is recessive. Thus, we inves...

In this longitudinal study, a mouse model of 4-nitroquinoline 1-oxide chemically induced tongue carcinogenesis was used to assess the ability of optical imaging with exogenous and endogenous contrast to detect neoplastic lesions in a heterogeneous mucosal surface. Widefield autofluorescence and fluorescence images of intact 2-NBDG-stained and proflavine-stained tissues were acquired at multiple...

The human breast cancer process and some aspects of experimental mammary cancer are compared in the light of Huxley's hypothesis that each neoplastic cell line may be viewed as a new obligate parasitic species derived from metazoan cells. Suff icient correlat ions are found to justify the hope that the viralinduced mouse mammary oncogenic process and the carcinogeninduced rat mammary system may...

Several key events in the multistep process of neoplastic transformation of rat tracheal epithelium (RTE) are described. Whether tracheal epithelium is exposed in vivo to carcinogenic agents or whether primary tracheal epithelial cells are exposed in vitro to carcinogens, initiated stem cells can be detected soon after the exposure by their ability to grow under selective conditions in culture....

The human breast cancer process and some aspects of experimental mammary cancer are compared in the light of Huxley's hypothesis that each neoplastic cell line may be viewed as a new obligate parasitic species derived from metazoan cells. Suff icient correlat ions are found to justify the hope that the viralinduced mouse mammary oncogenic process and the carcinogeninduced rat mammary system may...

The significance of circulating tumor cells (CTCs) has been discussed for more than a century. The advent of modern technology has allowed for more reliable detection of CTCs, and recent studies have provided compelling evidence that CTCs predict clinical response in metastatic colorectal cancer (mCRC). Combination of CTC analysis with independent prognostic factors has demonstrated powerful sy...

The aim of the study: present study is to evaluate accuracy fine needle aspiration cytology (FNAC) thyroid swellings and correlate with histopathological findings avoid unnecessary surgeries for benign lesions.
 Methods: this a prospective study. A total 55 cases were studied in Department Pathology at A.C.S Medical College Hospital. Fine was done correlated examination. Sensitivity, speci...

The human breast cancer process and some aspects of experimental mammary cancer are compared in the light of Huxley's hypothesis that each neoplastic cell line may be viewed as a new obligate parasitic species derived from metazoan cells. Sufficient correlations are found to justify the hope that the viral-induced mouse mammary oncogenic process and the carcinogen-induced rat mammary system may...