Abstract BACKGROUND DIPG remains a uniformly fatal disease in dire need of new therapies. There are currently no systemic therapies with proven efficacy against these tumors. To overcome barriers, we developed mRNA lipid particle (LP) vaccine that localizes to tumors and reticuloendothelial (RE) organs modulate both innate adaptive immunity poorly immunogenic like DIPG. OBJECTIVE We sought asse...

Cryptorchidism represents the most common endocrine disease in boys, with infertility more frequently observed in bilateral forms. It is also known that undescended testes, if untreated, lead to an increased risk of testicular tumors, usually seminomas, arising from mutant germ cells. In normal testes, germ cell development is an active process starting in the first months of life when the neon...

Omphalocele is a congenital malformation characterized by the failure of the abdominal walls to join together on the middle line as a consequence of a developmental defect. The diameter of the resulting opening may range from a few centimetres to the almost total absence of the abdominal wall. The diameter of the defect usually ranges from 3 to 8 cm. Naturally, the wider the opening, the more c...

BACKGROUND Tracheostomy was first observed in Egyptian drawings in 3600 BC and performed frequently during the 1800's diphtheria epidemic. OBJECTIVES The aim of this study was to elucidate the indications, complications, mortality rate, and the effect of pediatric tracheostomy on length of PICU or hospital stay. MATERIALS AND METHODS Demographic characteristics, diagnosis at admission, dura...

Survival is now the norm for children treated with radiotherapy and chemotherapy for childhood cancers. These children are now living to have children of their own. A Danish study of adverse health outcomes in the offspring of childhood cancer survivors and the offspring of the cancer survivor’s siblings is ongoing. The cumulative probability of congenital malformation is non significantly high...

INTRODUCTION An unplanned extubation (UEX) is a frequent and preventable adverse event of mechanical ventilation. OBJECTIVES To fnd out the causes of unplanned extubation and assess the use of a quality improvement intervention to reduce this event rate. POPULATION Patients with invasive mechanical ventilation for more than 12 hours over the period from May 1st 2010 and April 30th 2011 in a...

Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother's...

Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother’s...

OBJECTIVE The incidence of musculoskeletal tumors during pregnancy is very low. The aim of this study was to summarize our experience in treating a large cohort of pregnant patients diagnosed with these rare tumors. METHODS Women diagnosed with musculoskeletal tumors during pregnancy or immediately after delivery were identified retrospectively in our database between 1996 and 2006. Relevant ...

In order to test the effect of diphosphonates in inhibiting bone lysis induced by human tumors, neonatal mouse calvaria are cultured in sterile conditions in different media. Osteolysis is estimated by the amount of 45Ca released from bone to medium, the mice being given injections of 45Ca on their day of birth. An increased bone lysis is observed when calvaria are incubated in the same medium ...