PURPOSE In prematurely born population, a cascade of events from initial injury in the developing brain to morbidity may be followed. The aim of our study was to assess seizures in prematurely born children from birth up to 16 years and to evaluate the contribution of different seizures, and of neurological dysfunction to the seizure outcome. METHODS Pre- and neonatal data and data from neuro...

OBJECTIVES To analyze the relative frequencies of various epileptic seizures and to study the age at onset of different seizure types in Nepalese children. DESIGN Prospective study. SETTING Hospital outpatient based in Kathmandu, Nepal, between November 2001 to October 2002. PARTICIPANTS 50 children diagnosed as epilepsy excluding neonatal and febrile seizures. MAIN OUTCOME MEASURE Diag...

BACKGROUND Neonatal seizures (NS) affect approximately 1% of neonates. Clonic, tonic, myoclonic and subtle seizures are the common types. Birth asphyxia, sepsis, metabolic derangements, intracranial bleed, kernicterus, tetanus and 5th day fits are the common aetiologies. This study was planned to evaluate the types and causes of neonatal seizures. METHODS It was a descriptive case series cond...

Although neonatal seizures are quite common, there is controversy regarding their consequences. Despite considerable evidence that seizures may cause less cell loss in young animals compared with mature animals, there are nonetheless clear indications that seizures may have other potentially deleterious effects. Because it is known that seizures in the mature brain can increase neurogenesis in ...

Drug abuse in pregnancy is not uncommon, and the use of illicit opioids during pregnancy is associated with an increased risk of adverse outcomes. The aim of the study was to assess neonatal outcome of pregnancy with maternal addiction. Materials and Methods:   In this cohort study we assessed 100 pregnant women 15 -49 years old. To identify drug exposure was used self- questionnaire (Self-Repo...

Neonatal seizures are commonly caused by hypoxic and/or ischemic injury during birth and can lead to long-term epilepsy and cognitive deficits. In a rodent hypoxic seizure (HS) model, we have previously demonstrated a critical role for seizure-induced enhancement of the AMPA subtype of glutamate receptor (GluA) in epileptogenesis and cognitive consequences, in part due to GluA maturational upre...

PURPOSE To study the development of epilepsy following hypoxia-induced neonatal seizures in Long-Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures. METHODS Long-Evans rat pups were subjected to hypoxia-induced neonatal seizures at postnatal day 10 (P10). Epidural cortical electroencephalography (EEG) and hippocampal depth electrodes were use...

Neonatal sepsis is a common cause of neonatal morbidity and mortality in developing countries. It is a serious bacterial infection of blood with a clinical syndrome characterized by systemic signs of infection and bacteremia in the first month of life. Factors associated with positive blood culture and perinatal deaths among neonates are rarely described in developing countries. This study aime...

AIMS To determine the prevalence of unilateral neonatal cerebral infarction in infants born at 32 weeks gestation and above; to describe the clinical course, imaging results, and outcome of neonatal cerebral infarction; and to investigate possible aetiology. METHODS Twelve cases of unilateral neonatal cerebral infarction were identified from neonatal unit records for the years 1987-93. Each c...