OBJECTIVE The presence of enterobacteria such as Escherichia coli in the vagina of normal women is not synonymous with infection. However, vaginal E. coli may also cause symptomatic infections. We examined bacterial virulence properties that may promote symptomatic female reproductive tract infections (RTI) and neonatal sepsis. METHODS E. coli isolated as the causative agent from cases of vag...

Central nervous system infections due to multi- and pan-drug resistant Acinetobacter baumannii are an emerging problem in intensive care patients. A high mortality rate is seen in neonatal and central nervous system infections. Treatment can be prolonged and challenging. Polypeptide antibiotics remain one of the options but have poor cerebrospinal fluid (CSF) penetration. We present our experie...

BACKGROUND Diagnosis of bloodstream infections (BSI) in neonates is usually difficult due to minimal symptoms at presentation; thus early empirical therapy guided by local antibiotic susceptibility profile is necessary to improve therapeutic outcomes. METHODS A review of neonatal blood cultures submitted to the microbiology department of the Korle-Bu Teaching Hospital was conducted from Janua...

The most common clinical manifestation of gram negative Salmonella typhimurium infection is gastroenteritis. In Poland extraintestinal infections occur in about 0.4% of cases of reported salmonellosis. Poor personal hygiene practices of parents are the most common cause of Salmonella spp. infections in the neonatal period. The neonatal salmonellosis is significantly more frequently reported in ...

OBJECTIVE To study late onset systemic infections with coagulase negative staphylococci. METHODS Prospective longitudinal study of coagulase negative staphylococcal infection in 18 Australasian neonatal nurseries. RESULTS From 1991 to 2000 inclusive, there were 1281 cases of coagulase negative staphylococcal (CoNS) sepsis, comprising 57.1% of all late onset infections. The male/female ratio...

Background: Nosocomial infections or hospital-acquired infections constitute a global health problem. They lead to significant morbidity and mortality in both developed and resource-limited countries. The neonatal intensive care unit (NICU) is a suitable environment for disseminating these infections; underscoring the need for preventive intervention measures. Objectives: This review aims to hi...

Infant health care should be one of the first and most important tasks of every nation and one of the main programs of any government, because children, as a vulnerable group, have a special place in health services . Based on the findings, the number of live births in 2014 and 2015 was 39627 and 41575, respectively. The number of neonatal deaths in 2014 was 12.5%̧ while it was 10.5% in 2015. Th...

Maternal colonization with group B Streptococcus (GBS) during pregnancy increases the risk of neonatal infection by vertical transmission. However, it remains unclear whether treating all colonized women during labor exposes a large number of their neonates to possible adverse effects without benefit. We performed a meta-analysis to assess the effect of intrapartum antibiotic prophylaxis on neo...

..................................................................................................... 4 List of publications .................................................................................... 6 Abbreviations ............................................................................................. 7 Introduction .................................................................

A significant proportion of group B Streptococcus (GBS) neonatal disease, particularly late-onset disease, is associated with strains of serotype III, clonal complex (CC) 17. CC17 strains also cause invasive infections in adults. Little is known about the phylogenetic relationships of isolates recovered from neonatal and adult CC17 invasive infections. We performed whole-genome-based phylogenet...