Glucokinase hyperinsulinism is a rare variant of congenital hyperinsulinism caused by activating mutations in the glucokinase gene and has been reported so far to be a result of overactivity of glucokinase within the pancreatic beta-cell. Here we report on a new patient with difficulties to diagnose persistent hyperinsulinism and discuss diagnostic procedures of this as well as the other report...

OBJECTIVE To estimate and report the incidence and perinatal significance of hypoglycemia during the 100-g oral glucose tolerance test in pregnant women. METHODS Over a 3-year period, we analyzed the incidence and perinatal outcome of pregnant women who experienced hypoglycemia, defined as a plasma glucose level of 50 mg/dL or less while undergoing the 100-g oral glucose tolerance test. The s...

OBJECTIVES To assess the neonatal outcomes in newborns with intrauterine growth restriction (IUGR) in a Romanian population in a 3 level maternity unit. METHODS A matched case-control design, with one control for each patient was used. The case group comprised neonates with birth weight and birth length below the 10th percentile for the gestational age. Individual matching by gender and age o...

BACKGROUND Congenital hypopituitarism is an uncommon cause of neonatal cholestasis. Little is known about the effect of anterior pituitary hormone on hepatic functions. METHODS A retrospective review of the medical charts of eight infants with congenital hypopituitarism and neonatal cholestasis was performed. The results of endocrinological investigations, eye examinations, and magnetic reson...

Background It’s challenging for healthcare workers to detect neonatal hypoglycemia due its rapid progression and lack of aura symptoms. This may lead brain function impairment the newborn, placing a significant care burden on family creating an economic society. Tools early diagnosis are lacking. study aimed identify newborns at high risk developing by prediction model. Methods Using retrospect...

BACKGROUND Because of increased rates of respiratory complications, elective cesarean delivery is discouraged before 39 weeks of gestation unless there is evidence of fetal lung maturity. We assessed associations between elective cesarean delivery at term (37 weeks of gestation or longer) but before 39 weeks of gestation and neonatal outcomes. METHODS We studied a cohort of consecutive patien...

background preeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality. objectives the aim of this study was to determine the laboratory disorders in neonates born to preeclamptic mothers. patients and methods this descriptive-retrospective study was conducted in the neonatal units of shahid beheshti and shabihkhani hospitals on neonates born to preeclamptic mothers du...