The in vitro effect of trimethoprim on the inhibitory and bactericidal activity of amikacin against 20 strains each of Klebsiella pneumoniae and Serratia marcescens, 15 strains of Escherichia coli, and 10 strains of Pseudomonas aeruginosa was examined by the checkerboard technique in microtiter plates. Trimethoprim had a synergistic effect on the inhibitory and bactericidal activity of amikacin...

Quantitative inquiry into changes in the numbers of leprosy bacilli following the inoculation of suspensions of lepromatous tissue into a variety of special bacteriological media did not offer any suggestion of multiplication (1). A similar study of the bacilli in small cubes of nodule tissue incubated in or on bacteriological media, or in tissue culture solutions, also failed to reveal an incr...

The detection of tubercle bacilli in the sputum is regarded by many as of unfavorable prognostic significance, regardless of the number detected and the frequency with which they are found. This study is an attempt to evaluate the prognostic significance of small numbers of tubercle bacilli detected in the sputum by concentration methods. Sputum with modified Gaffky counts of i, ii, or iii were...

Much has been written and said in recent years regarding the classification and significance of the Enterobacteriaceae. These organisms, without a doubt, exceed all other gram-negative bacteria as etiologic agents of disease, and because of their predominance they have deserved the attention that they have received. With the emphasis placed on these fermenting bacteria, however, a dearth of inf...

The activity of a new semisynthetic penicillin, carbenicillin, was determined against 241 strains of gram-negative bacilli with the tube-dilution technique. Of 143 strains of Pseudomonas sp., 99 had a minimal inhibitory concentration of 200 to 300 mug/ml. The majority of strains of Escherichia coli and Proteus spp. were sensitive to this antibiotic, with minimal inhibitory concentrations of 25 ...

INTRODUCTION Antibiotic resistance in gram-negative bacilli is an area of increasing importance. This prospective study was performed to survey antibiotic resistance in Escherichia coli (E. coli), Klebsiella spp., Pseudomonas aeruginosa and Acinetobacter spp. over a 1-year period. MATERIALS AND METHODS Non-duplicate isolates of E. coli, Klebsiella spp., P. aeruginosa and Acinetobacter spp. we...