Lyso-7 is a novel synthetic thiazolidinedione, which receptor (pan) agonist of PPAR ?,?/?,? with anti-inflammatory activity. We investigated the cardiotoxicity free in vitro (4.5–450 nM), and loaded polylactic acid nanocapsules (NC) vivo (Lyso-7-NC, 1.6 mg/kg). In previous work, we characterized Lyso-7-NC. administered intravenously Lyso-7, Lyso-7-NC, control, blank-NC once day for seven days m...