Antibiotics are metabolic by-products of complex biosynthetic pathways in microorganisms. They are usually produced by aerobic spore-forming bacteria in the genera Bacillus and Streptomyces and in the Fungi Penicillium and Cephalosporium. Antimicrobials such as bacteriocins are inhibitory peptides or proteins, which have bactericidal effects on micro-organisms closely related to the producer. T...

Interest in the development of bioprocesses for the production or extraction of bioactive compounds from natural sources has increased in recent years due to the potential applications of these compounds in food, chemical, and pharmaceutical industries. In this context, solid-state fermentation (SSF) has received great attention because this bioprocess has potential to successfully convert inex...

This work aimed at the development of biodegradable nanocapsules as carriers of two bioactive compounds, 5-aminosalycilic acid and glycomacropeptide. Nanocapsules were produced through layer-by-layer (LbL) deposition of chitosan (CH) and alginate (ALG) layers on polystyrene nanoparticles. The bioactive compounds were incorporated on the third layer of the nanocapsules being its encapsulation ef...

During the brewing process, lipid oxidation can lead to undesirable flavours in beer [I]. Naturally occuring phenols in malt (germinated barley) have proven their effectiveness as antioxidants [2]. Ferulic acid (4-hydroxy-3methoxy cinnamic acid) is the most abundant phenolic acid in barley. It acccounts for 0.14% of dry matter in barley grains 131, and it is mainly esterified to arabinofuranosy...

Natural product (NP)-inspired design principles provide invaluable guidance for bioactive compound discovery. Pseudo-natural products (PNPs) are de-novo combinations of NP fragments to target biologically relevant chemical space not covered by NPs. We describe the and synthesis apoxidoles, a novel pseudo-NP class, whereby indole- tetrahydropyridine linked in monopodal connectivity found nature....

A new bioactive compound, namely desmodianone H(1), and another known compound uncinanone B(2) were first isolated using bioactivity-guided isolation from the leaves of Lespedeza maximowiczii and structures were elucidated by comprehensive analysis of their nuclear magnetic resonance and mass spectrometry data. Compounds 1 and 2 exhibited strong inhibitory effects on mushroom tyrosinase activity.

Cancer is one of the most severe illnesses afflicting mankind these days and certainly, the second one most lethal ailment after coronary heart ailment. There are various specific styles of cancer labeled with the aid of the type of cellular that is initially affected, and these consist of cervical most cancers, skin most cancers, leukemia, lung most cancers, liver cancer, breast cancer, prosta...

Cancer is one of the most severe illnesses afflicting mankind these days and certainly, the second one most lethal ailment after coronary heart ailment. There are various specific styles of cancer labeled with the aid of the type of cellular that is initially affected, and these consist of cervical most cancers, skin most cancers, leukemia, lung most cancers, liver cancer, breast cancer, prosta...

The need for therapeutics to overcome development of existing diseases research discover new lead agents. In the face public health challenges worldwide, natural medicines play a pivotal role in innovative drug discovery. Network pharmacology can easily construct complicated poly-pharmacology network based on compound, biological function, and bioactive target proteins, which meets overall feat...

The discovery of novel bioactive molecules advances our systems-level understanding of biological processes and is crucial for innovation in drug development. For this purpose, the emerging field of chemical genomics is currently focused on accumulating large assay data sets describing compound-protein interactions (CPIs). Although new target proteins for known drugs have recently been identifi...