Antibiotics and antifungals are needed in the patient's dentures because acrylic resin denture base can be a breeding ground for Streptococcus mutans Candida albicans colonies. Indonesia has biodiversity consisting of thousands plant species so that it becomes an opportunity development ofsecondary metabolites healthcare industry. Some natural materials used as antibiotics, anti-inflammatory, a...

Fungal infections, from mild itching to fatal lead chronic diseases and death. Antifungal agents have incorporated chemical compounds natural products/phytoconstituents in the management of fungal diseases. In contrast antibacterial research, novel antifungal drugs progressed more swiftly because their existence negligible resistance infections bioactivities. Nanotechnology-based carriers gaine...

Dermatophytosis and superficial mycosis are a major global public health problem that affects 20-25% of the world's population. The increase in fungal resistance to the commercially available antifungal agents, in conjunction with the limited spectrum of action of such drugs, emphasises the need to develop new antifungal agents. Natural products are attractive prototypes for antifungal agents d...

Thymol is a natural plant-derived compound that has been widely used in pharmaceutical and food preservation applications. However, the antifungal mechanism for thymol against phytopathogens remains unclear. In this study, we identified the antifungal action of thymol against Fusarium graminearum, an economically important phytopathogen showing severe resistance to traditional chemical fungicid...

BACKGROUND Medicinal plants have traditionally been used in many parts of the world as alternative medicine. Many extracts and essential oils isolated from plants have disclosed biological activity, justifying the investigation of their potential antimicrobial activity. In this study, the in vitro antifungal activity of six Brazilian Cerrado medicinal plant species were evaluated against clinic...

Debates about the possible negative effects of synthetic preservatives have renewed consumer interest towards natural agents for extension of the product viability and the protection from microbial spoilage. For these reasons, there are current studies on the application of essential oils, extracts, and their components extracted from spices and other aromatic plants, as alternative biopreserva...

Pathogenic fungi constitute one of the main infectious agents in plants, causing alterations during developmental stages including post-harvest. Phytopathogenic fungi are controlled by synthetic fungicides; however, the use of these is progressively restricted due to both, the harmful effects of pesticides on the environment and human health and the appearance of highly resistant fungal strains...

Fungal infections have become a major public health problem, growing in number and severity in recent decades due to an increase of immunocompromised patients. The use of therapeutic agents available to treat these fungal infections is limited by their toxicity, low bioavailability, antifungal resistance, and high cost of treatment. Thus, it becomes extremely important to search for new therape...

A common consequence of using agricultural fungicides is the development of resistance by fungal pathogens, which undermines reliability of fungicidal effectiveness. A potentially new strategy to aid in overcoming or minimizing this problem is enhancement of pathogen sensitivity to fungicides, or "chemosensitization." Chemosensitization can be accomplished by combining a commercial fungicide wi...

We investigated the antifungal effects of sesamol (Ses), a natural phenolic compound, and exemplified that it could be mediated through disruption of calcineurin signaling pathway in C. albicans, a human fungal pathogen. The repertoire of antifungal activity not only was limited to C. albicans and its six clinical isolates tested but also was against non-albicans species of Candida. Interesting...