Background Inflammation in the nasal mucosa has been shown to correlate with the development of CRSwNP (chronic rhinosinusitis with nasal polyps). The mechanism behind this is not fully understood but changes in the activity of the immune system might contribute to the growth of polyps. The present study focuses on the potential role of MHC II (major histocompatibility complex class II). These ...

Endoscopy is needed for reliable evaluation of the treatment of nasal polyposis. In this study, we compared the reproducibility of various score systems for staging nasal polyposis and the inter-individual variations between investigators. The mass of the polyps was assessed by five methods, three new techniques (numbers 1, 2 and 3) and two established ones (numbers 4 and 5). These were: 1, lat...

Although CD4(+) T cells are recognized to play an important role in the inflammatory response of nasal polyps (NPs), the biological functions of CD8(+) T cells in polypogenesis remain unclear. In this study, we analyzed cell markers, cytokine expression and transcription factors in IL-21-expressing CD8(+) T cells in polyp tissues of NP patients. The results showed that the majority of IL-21-pro...

PURPOSE Chronic rhinosinusitis with nasal polyps (CRSwNP), a mainly Th2 cytokine-mediated disease, often involves mucus secretion. Recent evidence suggests that transmembrane protein 16A (TMEM16A), a calcium-activated Cl- channel (CaCC), can regulate mucus secretion from airway epithelium by transepithelial electrolyte transport and hydration. However, the role of TMEM16A in mucin production/se...

Introduction Nasal polyps are benign mucosal disorders extending to lumen by proliferating in nasal cavity as a result of mucosal inflammation. NP are the most common reason of nasal masses with a prevalence of 1-4% and it is more common in male gender (1, 2). It is a multifactorial disease with unclear etiology. Allergy, chronic infection and mechanic, immunological and biochemical factors are...

OBJECTIVES To evaluate the ocular complication of functional endoscopic sinus surgery in patients with chronic sinus disease. METHODS In a prospective descriptive, cross-sectional study without control group, 53 patients who underwent functional endoscopic sinus surgery for refractory chronic sinus diseases were evaluated. Patients underwent a complete Otolaryngology and Ocular examination an...