Drug nanocrystals are a versatile option for drug delivery purposes, and while the number of poorly soluble drug materials is all the time increasing, more research in this area is performed. Drug nanocrystals have a simple structure-a solid drug core is surrounded by a layer of stabilizing agent. However, despite the considerably simple structure, the selection of an appropriate stabilizer for...

Our work investigates the precipitation mechanism of a seeded calcium carbonate reaction, by using cryogenic TEM to observe the early stages of the reaction. The early precipitation of a hydrated phase is proposed as an intermediate phase before transformation into calcite. Thermodynamic modeling in conjunction with pH, surface potential measurements, and colloidal stability modeling demonstrat...

In this work matrix based nanoparticulate polymer systems have been designed using the diacrylate derivative of the well-known biocompatible polymer, poly(ethylene glycol) (PEG). This has been crosslinked using bifunctional (ethyleneglycol dimethacrylate) and tetrafunctional (pentaerythritol tetraacrylate) crosslinkers in varied concentrations (10-90%) to result in a polymeric network. The cros...

Bioactive products from snail slime of “Helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. However, the poor pharmacokinetics characteristics of these natural compounds limit their use. Nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug del...

objective(s):investigation of phase diagram of various drug formulations is effective to predict different phase region of drugs to detect final formula. the purpose of this research was to develop the ternary phase diagrams for a drug microemulsion system consisting of cucurbita pepo (pumpkin) oil, surfactant (tween 80) and deionized water. materials and methods:an electrical conductivity was ...

Several dry processing techniques are assessed to elaborate metallic nanocomposite powders dedicated powder-bed-based (PBB) additive manufacturing as laser-powder bed fusion (L-PBF) and Binder Jetting (BJ). Electrostatic assembly of nanosized silicon carbide (35 nm) particles at the surface gas atomized aluminium (15-53 ?m) is performed using mixers covering a range mixing energy from rotative ...

The photodegradation of Ponceau-S dye was investigated using UV radiation in presence of nanosized Fe2 O3 .Removal efficiency of Ponceau-S was sensitive to the operational parameters such as dye concentration, catalyst dose, pH, contact time, TOC and COD. The photocatalytic treatment of red colored Ponceau-S dye by magnetic nano semiconductor (Fe2 O3 )is an effective, economic and faster mode. ...

We demonstrate here that G-quadruplex structure can form and exhibits strong stability in nanosized water pools, providing new insight into investigating G-quadruplexes in the cellular environment.