The lack of trypsin in the intestines may end up with malnutrition; thus, replacement therapy is required such cases. main objective this study to formulate and evaluate polymeric nanocapsule (PNC) systems able deliver small minimal release stomach maximum biological activity. Four formulations were prepared by double emulsion/evaporation method as w/o/w s/o/w. Particle size, encapsulation effi...

As salicylic acid (SAC) is an extensively used pharmaceutical, discharge of SAC into the environment has caused serious threats to ecology in view its toxicity. Therefore, SO4•−-involved chemical oxidation methods have been employed for eliminating SAC. Since monopersulfate (MPS) become a popular reagent producing SO4•−, alternative heterogeneous Co-based catalyst proposed by using Co-coordinat...

OBJECTIVES The ability to target conventional drugs efficiently inside cells to kill intraphagosomal bacteria has been a major hurdle in treatment of infective diseases. We aimed to develop an efficient drug delivery system for combating infection caused by Salmonella, a well-known intracellular and intraphagosomal pathogen. Chitosan-dextran sulphate (CD) nanocapsules were assessed for their ef...

High definition self-assemblies, those that possess order at the molecular level, are most commonly made from subunits possessing metals and metal coordination sites, or groups capable of partaking in hydrogen bonding. In other words, enthalpy is the driving force behind the free energy of assembly. The hydrophobic effect engenders the possibility of (nominally) relying not on enthalpy but entr...

Highly-efficient delivery of macromolecules into cells for both imaging and therapy (theranostics) remains a challenge for the design of a delivery system. Here, we suggested a novel hybrid protein-lipid polymer nanocapsule as an effective and nontoxic drug delivery and imaging carrier. The biodegradable nanocapsules showed the typical double emulsion features, including fluorescently labeled b...

Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Here we describe a strategy using crosslink-stabilized lipid nanocapsules (NCs) as carriers to transport such membrane-penetrating particles into tumor cells and promote their transfer to intracellular membrane...