UV-visible and Fluorescence spectroscopic methods were employed to study the interaction of human serum albumin (HSA) with Valacyclovir Hydrochloride. Additionally, molecular dynamics and molecular docking simulations were used to visualize and specify the binding site of Valacyclovir Hydrochloride. The Stern-Volmer and van't Hoff equations along with spectroscopic observations, were used to de...

Clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and Tourette syndrome. The quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. Therefore, the aim of this study was to establish the conditions for two spectroph...

The inhibitory effects of three topical anesthetics of various concentrations on the growth of Pullularia pullulans, Debaryomyces hansenii, and on pigment production by P. pullulans were investigated. The topical anesthetics were benoxinate hydrochloride, proparacaine hydrochloride, and tetracaine hydrochloride. In decreasing order, the inhibiting effects of the drugs on growth were benoxinate,...

A new, simple, and sensitive spectrophotometric method for the determination of certain tricyclic antidepressants, belonging to the dibenzazepine class of drugs, has been developed. The proposed method is based on the reaction of imipramine hydrochloride (IPH), desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH), trimipramine maleate (TPM) or opipramol (OPP) with iron(III), and su...

Materials and methods Our research took place in a private psychiatric clinic (2005-2009) and focused on the effectiveness of a certain pharmacological combination administered to a sample of 37 patients, in an attempt to control the alcohol withdrawal syndrome. The pharmacological combination comprised 30mg-60mg Chlordiazepoxide hydrochloride, 300mg-500mg Triapride hydrochloride, 300mg-500mg H...

Basilar Arterial Flow Changes Elicited by Hydralazine Hydrochloride, Isoxsuprine Hydrochloride and Nylidrin Hydrochloride • The influence of infusion of hydralazine, isoxsuprine or nylidrin on blood flow in the basilar artery and on systemic blood pressure was investigated in anesthetized dogs. The drugs were administered individually in 1-mg and 2-mg doses and in various combinations of 1 mg e...

ABSTRACT: The effect of methods to remove protein content on the properties glucosamine hydrochloride from shells white leg shrimp (Litopenaeus vannamei) and black tiger (Penaeus monodon) was investigated. Chitin obtained by demineralization in 6% HCl for 12h, deproteinization two different (first group soaked 8% NaOH 36h second treated Alcalase enzyme at concentration 0.2% 36h). Two samples we...

Major use Chlorpromazine hydrochloride (CPH) belongs to antipsychotic drugs, also called neuroleptics; and it is mainly used for the treatment of neurological disorders. CPH has sedative, hypotensive and antiemetic properties. CPH, which is an aliphatic phenothiazine, was first synthesized in 1952. It was extensively studied and used as a model for a big class of neuroleptic agents. Haloperidol...

PURPOSE In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated. METHODS Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochloride, and diphenhydramine hydrochloride were studied. The antibacterial activities of these prep...