A 32-year-old woman had several brownish and pruritic lesions over her left buttock and leg that had been present since she was 12 years old. She observed a progressive increase in size and number of the lesions, with increased sweating on and around them. Examination revealed several brownish, irregular nodules, 1–1.5 cm in diameter, and firm to palpation, along the lower left limb and followi...

Aim:Spitz naevus is a benign melanocytic tumour with distinct histopathological features of spindle-shaped melanocytes. An understanding genetic aberrations can help to characterise the different subsets Spitzoid neoplasms. Anaplastic lymphoma kinase (ALK) tyrosine receptor that was first described in pathogenesis anaplastic large cell (ALCL). ALK mutations have been reported up 10% Spitz tumou...

While population screening for melanoma is not recommended, those at high risk could lead to earlier detection and improved patient outcomes. Current stratification largely based on subjective clinical assessment self-report. This time-consuming dependent the experience understanding of person reporting. Therefore, improved, standardized methods are required. We developed an automated skin surf...

Sir, Porokeratotic eccrine ostial and dermal duct naevus (PEODDN) is a rare disorder of keratinization with eccrine involvement that histologically presents a cornoid lamella exclusively associated with eccrine ostia and the underlying sweat ducts (1). It is an expression of genetic mosaicism (2) and is characterized by asymptomatic grouped keratotic papules and plaques with a linear distributi...

THE association of buphthalmos with facial naevus has received attention in ophthalmological literature from time to time over a period of many years, and a recent revival of interest in the subject has been stimulated by the appearance of articles by Cushing, Parkes WVeber, Aynsley and others. About the time of the appearance of Aynsley's paper the following very early case came under my notic...

A 71-year-old woman with the blue rubber bleb naevus syndrome experienced 4 episodes of self-limiting unilateral exophthalmos. Is is suggested that a vascular malformation in the orbit is responsible for this phenomenon. A biopsy sample was taken of one of the cutaneous lesions and studied by light and transmission electron microscopy. The histological appearances are discussed in relation to p...

A case of basal cell naevus syndrome is presented. The jaw cysts were proved histopathologically to be odontogenic keratocysts. The multiple naevoid lesions on the skin were identified as basal cell carcinoma. Intracranial calcification is illustrated to a degree not previously reported in a case with this syndrome. The importance of identifying this syndrome is discussed and its presentation i...