A newsynthetic route has been developed for the total synthesis of ozenoxacin. In this avoided toxic heavy metals and synthesised key intermediate_7-bromo-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid by simply insertion Cyclopropyl amine into 4-oxo-4H-chromene-3-carboxylic intermediate, Then intermediate carboxylic acidundergoesSuzuki coupling with boronated ester deacety...

The title compound, C(10)H(7)FO(4), is an inter-mediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione. The di-hydro-pyran-one ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the mol-ecules are linked into zigzag chains along [100] by O-H⋯O hydrogen bonds and C-H⋯π inter-...

Molecular crystals have been prepared from pentafluorophenylphosphonic acid (4). These include 2C6F5PO3H2·H2O (4·4·H2O), [(C6F5PO3H–)(H3O+)]·C6F5PO3H2 (4·4–·H3O+), [(C6F5PO3H–)(NH4+)]·C6F5PO3H2 (4·4–·NH4+), [(C6F5PO3H–)(Me2NH2+)] (4–·DMA+), [(C6F5PO3H–)(Me2NH2+)]·H2O (4–·DMA+·H2O), [(C6F5PO3H–)(Me2NH2+)]·C6F5PO3H2 (4·4–·DMA+), [(C6F5PO3H–)(Me2NH2+)0.5(NH4+)0.5] (4–·DMA+·NH4+), and [(C6F5PO3H–)(...

sulfonic acid functionalized sba-15 as a nanoporous acid catalyst was used in the synthesis of 2-aryl benzoxazoles 4 by the condensation of 2-aminophenol 1 and benzoyl chlorides 2 under microwave irradiation in solvent free reaction conditions. the advantages of this methodology are good product yields (60-98%), being environmentally benign, short reaction times and easy work up.

L-Alanine, L-threonine, L-valine, D-cystine and three derivatives of thiazole-4-carboxylic acid (thiostreptin, 1-aminomethylthiazole-4-carboxylic acid and thiostreptoic acid) were isolated from the acid-hydrolysate of thiopeptin B. In addition, the presence of dehydrobutyrine and dehydroalanine residues in the antibiotic was determined. Other components remain unidentified.

Five new cobalt(ii) coordination architectures, {[Co(L)2(H2O)2]·2H2O·2NO3}n (), {[Co(L)(ppda)]·2H2O}n (), {[Co2(L)(ppda)2]2·H2O}n (), {[Co(L)(nba)]·5H2O}n (), and {[Co(L)(oba)]2·3H2O}n (), have been constructed from the rigid ligand L [L = 2,8-di(1H-imidazol-1-yl)dibenzofuran] and different flexible carboxylic acid ligands [H2ppda = 4,4'-(perfluoropropane-2,2-diyl)dibenzoic acid, H2nba = 4,4'-a...

3-methyl-1-sulfonic acid imidazolium tetrachloroferrate {[Msim]FeCl4} as an efficient sulfur catalyst was prepared and applied, as an efficient catalyst, for the cross-aldol condensation reaction between cycloalkanones and arylaldehydes to give α,αʹ- bis(arylidene)cycloalkanones in high yields and short reaction times at 75 °C under solvent-free conditions. 3-methyl-1-sulfonic acid imidazolium...

Chemical investigation of the fungus Penicillium sp. SCSIO Ind16F01 derived from deep-sea sediment sample afforded a new xanthone, 3,8-dihydroxy-2-methyl-9-oxoxanthene-4-carboxylic acid methyl ester (1) and a new chromone, coniochaetone J (2), together with three known xanthones, 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), 7,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-...

The differential scanning colorimetry (DSC) thermooxidative stability of new copolymers styrene-sulfonic acid and N-vinylimidazole obtained by radical copolymerization in a DMF solution an argon atmosphere has been studied