Ringfused bicyclic 2-pyridones exhibit interesting biological properties against pili assembly in uropathogenic Escherichia coli (Pinkner, J. S. et al. Proc. Natl. Acad. Sci. U. S. A.2006, 103, 17897-17902; Åberg, V. et al. Org. Biomol. Chem.2007, 5, 1827-1834) as well as curli formation (Cegelski, L. et al. Nat. Chem. Biol.2009, 5, 913-919). In the search for new ring-fused central fragments...

In the crystal structure of the title compound, [V(C(12)H(17)N(2)O)O(2)], the vanadium(V) centre is five-coordinate in a distorted square-pyramidal environment. The three atoms of the deprotonated Schiff base and a double-bonded O atom comprise the basal plane. N-H⋯O hydrogen bonds lead to a zigzag chain structure parallel to [001].

Pirfenidone, a pyridone compound, is an effective and novel antifibrotic agent. In this article, we describe the design, synthesis and activity evaluation of novel antifibrotic agents, 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones modified with carbohydrate. Most of the title compounds exhibited comparable or better inhibitory activity than fluorofenidone. Notably, compound 19a demonst...

In the course of experiments designed to elucidate the structure of reduced diphosphopyridine nucleotide (DPNH) (12), it became necessary to prepare the 2and 6-pyridones of iV-methylnicotinamidel by oxidation of the latter. Huff (5) has described the preparation of N’-methyl-6-pyridone-3-carboxylic acid by alkaline ferricyanide oxidation of either trigonelline or N’-methylnicotinamide. The acid...

The nonnucleoside reverse transcriptase (RT) inhibitors comprise a class of structurally diverse compounds that are functionally related and specific for the human immunodeficiency virus type 1 RT. Viral variants resistant to these compounds arise readily in cell culture and in treated, infected human. Therefore, the eventual clinical usefulness of the nonnucleoside inhibitors will rely on a th...