Wang, Yan, and Yoram Rudy. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am J Physiol Heart Circ Physiol 278: H1019–H1029, 2000.—Heterogeneity of myocardial structure and membrane excitability is accentuated by pathology and remodeling. In this study, a detailed model of the ventricular myocyte in a multicellular fiber was used t...

Kopp, Ulla C., Donna M. Farley, Michael Z. Cicha, and Lori A. Smith. Activation of renal mechanosensitive neurons involves bradykinin, protein kinase C, PGE2, and substance P. Am J Physiol Regulatory Integrative Comp Physiol 278: R937–R946, 2000.—Increased renal pelvic pressure or bradykinin increases afferent renal nerve activity (ARNA) via PGE2-induced release of substance P. Protein kinase C...

Individuals with REM sleep behaviour disorder are at significantly higher risk of developing Parkinson’s disease. Here we examined visual short-term memory deficits—long associated with Parkinson’s disease—in patients with REM sleep behaviour disorder without Parkinson’s disease using a novel task that measures recall precision. Visual short-term memory for sequentially presented coloured bars ...

Hoit, Brian D., Vivek J. Kadambi, Daniel A. Tramuta, Nancy Ball, Evangelia G. Kranias, and Richard A. Walsh. Influence of sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution. Am. J. Physiol. Heart Circ. Physiol. 278: H958–H963, 2000.—Mechanical and relaxation restitution represent the restoration of contractile force and relaxation, respectively, in premature beats h...

Epigenetic changes are inherited alterations in DNA that affect gene expression and function without altering the DNA sequence. DNA methylation is one epigenetic process implicated in human disease that is influenced by diet. DNA methylation involves addition of a 1-C moiety to cytosine groups in DNA. Methylated genes are not transcribed or are transcribed at a reduced rate. Global under-methyl...

He, L., B. Dinger, and S. Fidone. Cellular mechanisms involved in carotid body inhibition produced by atrial natriuretic peptide. Am J Physiol Cell Physiol 278: C845–C852, 2000.—Atrial natriuretic peptide (ANP) and its analog, atriopeptin III (APIII), inhibit carotid body chemoreceptor nerve activity evoked by hypoxia. In the present study, we have examined the hypothesis that the inhibitory ef...

Davidson, Alec J., Susan L. T. Cappendijk, and Friedrich K. Stephan. Feeding-entrained circadian rhythms are attenuated by lesions of the parabrachial region in rats. Am J Physiol Regulatory Integrative Comp Physiol 278: R1296– R1304, 2000.—Rats anticipate daily restricted meals with increased approaches to a feeder and an increase in core body temperature. Food anticipatory activity (FAA) is t...

FUSHUN YU,1,2 STEN GÖTHE,3 LILIAN WIKSTRÖM,3 DOUGLAS FORREST,4 BJÖRN VENNSTRÖM,3 AND LARS LARSSON1,2 1Noll Physiological Research Center and Department of Cellular and Molecular Physiology, Pennsylvania State University, University Park, Pennsylvania 16802-6900; 2Department of Clinical Neuroscience, Karolinska Institute/Karolinska Hospital, 171 76 Stockholm; 3Laboratory of Developmental Biology...

Schäfer, C., Y. V. Ladilov, B. Siegmund, and H. M. Piper. Importance of bicarbonate transport for protection of cardiomyocytes against reoxygenation injury. Am J Physiol Heart Circ Physiol 278: H1457–H1463, 2000.—Isolated cardiomyocytes from adult rats were incubated in anoxic bicarbonate-buffered media at extracellular pH (pHo) 6.4 until a cytosolic Ca21 overload and intracellular pH (pHi) of ...

Daun, Jane M., Richard W. Ball, and Joseph G. Cannon. Glucocorticoid sensitivity of interleukin-1 agonist and antagonist secretion: the effects of age and gender. Am J Physiol Regulatory Integrative Comp Physiol 278: R855– R862, 2000.—Interleukin-1 (IL-1) is a primary mediator of inflammation that is regulated, in part, by the hypothalamicpituitary-adrenal axis. The purpose of this study was to...