Plasma levels of plasminogen activator inhibitor type-1 (PAI-1), beta-thromboglobulin (beta TG), and fibrinopeptide A (FPA) were followed over 24 hours in 30 patients treated with alteplase for acute myocardial infarction. Samples were taken at baseline (T Oh), after 90 minutes (under alteplase, no heparin, T 1.5h), after 120 minutes (under alteplase and heparin, T 2h), 30 minutes after thrombo...

In the title salt, C(8)H(16)N(2)O(4) (2+)·2H(2)PO(4) (-)·2H(2)O, the piperazine ring is located around an inversion center and adopts a chair conformation. The dihydrogen phosphate anions and free water mol-ecules are linked via O-H⋯O hydrogen bonds into two-dimensional hydrogen-bonding layers, which are further connected through O-H⋯O and N-H⋯O hydrogen bonds involving the protonated piperazin...

A straightforward one-pot route for the synthesis of a new 4-phenyl-1,2,5,6-tetraazafluoranthen-3(2H)-one is reported form direct hydrazinolysis triketo ester and hydrazine hydrate in ethanol. 4-Phenyl-1,2,5,6-tetraazafluoranthen-3(2H)-one was subjected to aza-Michael addition N-alkylation on reaction with set alkylating agents presence K2CO3. Hydrazinolysis hydrazide conversion thiosemicarbazi...

The WST-1 assay is an efficient test for cell viability measurement and the standard incubation time is 2h. In order to test if one-time addition of WST-1 reagent can reflect the relative cell viability trend of the testing agents at different time points, the effects of 2h standard incubation time and long term incubation time (2h+24h, 2h+48h) of WST-1 were compared in the rat airway smooth mu...

In this work, some 2-nonsubstituted/2-methyl-/2-(2-acetyloxyethyl)-6-[4-(substituted pyrrol-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone, derivatives and 2-nonsubstituted/2-methyl- 4-[4-(substituted pyrrol-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesised by reacting hexan-2,5-dion or 1-aryl-3-carbethoxypent-1,4-diones with corresponding 2-substituted/nonsubstituted 6-(4'-aminophenyl...

The asymmetric unit of the title compound, (C(11)H(18)N(2))(2)[CdCl(6)]·2H(2)O, consists of one 1-benzyl-piperazine-1,4-diium dication, one water mol-ecule and one-half of a [CdCl(6)](4-) anion, located on an inversion centre. The crystal packing is governed by an extensive three-dimensional network of inter-molecular O-H⋯Cl, C-H⋯Cl, N-H⋯O and N-H⋯Cl hydrogen bonds, two of them bifurcated.

New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, 1H NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-...

The title compound, C(12)H(18)N(8) (2+)·2NO(3) (-)·2H(2)O, was synthesized unexpectedly from 3-amino-1-methyl-1,4,5,6-tetra-hydro-pyrrolo-[3,4-c]pyrazol-5-ium chloride and cerium(IV) ammonium nitrate. The cation has a crystallographically imposed centre of symmetry. In the crystal, the ions and water mol-ecules are linked via O-H⋯N, N-H⋯O and O-H⋯O hydrogen bonds into a three-dimensional network.

Chandramouli, Visvanathan, Karin Ekberg, William C. Schumann, John Wahren, and Bernard R. Landau. Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E717–E723, 1999.— Healthy subjects ingested H2O. 2H enriched the hydrogen bound to carbon 1 of blood glucose 1.3 to 1.8 times more than the hyd...