H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol 2001; 38: 1644–50. [13] Buerke M, Rupprecht HJ, Vom DJ et al. Sodium–hydrogen exchange inhibition: novel strategy to prevent myocardial inju...

This study aimed to investigate the protective effects and the mechanisms underlying these effects of isoflurane preconditioning in the delayed phase of myocardial ischemia-reperfusion injury. We randomly divided 30 healthy male New Zealand white rabbits into three groups with 10 rabbits in each group as follows: sham operation group (C group), ischemia-reperfusion group (I/R group), and 2.0% i...

BACKGROUND The anti-inflammatory cytokine interleukin-10 (IL-10) has been detected in the plasma of patients with myocardial ischemia/reperfusion. The aim of our study was to investigate the role of endogenously produced IL-10 in myocardial ischemia/reperfusion. METHODS AND RESULTS In the present study, we used wild-type and IL-10-deficient mice subjected to myocardial ischemia/reperfusion. S...

Background Impaired microvascular reperfusion (no-reflow) and unsuccessful infarct-related artery (IRA) revascularization are associated with worse clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Successful reperfusion can be estimated by epciardial and microvascular flow. Both of them can be ev...

Coronary heart disease is a major cause of death in the western world. Although essential for successful recovery, reperfusion of ischemic myocardium is inevitably associated with reperfusion injury. To investigate a potential protective role of ADAMTS13, a protease cleaving von Willebrand factor multimers, during myocardial ischemia/reperfusion, we used a mouse model of acute myocardial infarc...

The aim of the present study was to investigate the effects of sabiporide, a potent and selective NHE1 inhibitor, on myocardial ischemia-induced arrhythmias and myocardial infarction and the possible pathways related to the cardioprotection afforded by sabiporide treatment. Anesthetized rats were subjected to myocardial ischemia via left main coronary artery occlusion for 30 minutes, followed b...

outline The theme for the 15th annual SA Heart Congress for 2014, ‘Bridging the divide’ between best practice and current challenges in the management of cardiovascular conditions, inspired this editorial on the feasibility of implementing the European Society of Cardiology ‘Stent-for-Life’ initiative in sub-Saharan Africa or alternate measures of ensuring early reperfusion for myocardial ischa...

Background Impaired microvascular reperfusion (no-reflow) and unsuccessful infarct-related artery (IRA) revascularization are associated with a worse clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Reperfusion can be identified by epicardial or microvascular flow determined by angiography as Thr...

Background: myocardial ischemia-reperfusion (I/R) injury may occur in a variety of clinical set tings and this remains a significant problem. Oxygen free radi cals, produced on reperfusion have been shown to play a major role in myocardial I/R injury. Various therapeutic effects have been described for Crataegus. Additionally, it has been presented that Crataegus has protective effect against i...

Primary percutaneous coronary intervention and thrombolysis remain therapies of choice for patients presenting with ST-segment elevation myocardial infarction (STEMI). Clinical outcome in the management of acute STEMI is dependent on myocardial reperfusion time and reperfusion strategies. Optimisation of these strategies should take into consideration logistical limitations of the local medical...