although thallium-201 exercise scintigraphy has been established for the detection of myocardial ischemia and viability, little is known regarding the myocardial thallium-201 kinetics during angioplasty. herein, we report a 77-year old man with angina pectoris, in whom serial myocardial imaging after a single dose of thallium-201 was helpful in identifying not only the culprit lesion and myocar...

Myocardial ischemia (MI) resulting in infarction is an important cause of mortality and morbidity worldwide. Acute ischaemia rapidly impairs myocardial contractile function. Myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. Hibernation is now thought to be the consequence o...

Nitric oxide (NO) inhibits myocardial glucose transport and metabolism, although the underlying mechanism(s) and functional consequences of this effect are not clearly understood. We tested the hypothesis that NO inhibits the activation of AMP-activated protein kinase (AMPK) and translocation of cardiac glucose transporters (GLUTs; GLUT-4) and reduces lactate production. Ischemia was induced in...

BACKGROUND Type 2 diabetes and the metabolic syndrome are associated with impaired diastolic function and increased heart failure risk. Animal models and autopsy studies of diabetic patients implicate myocardial fibrosis, cardiomyocyte hypertrophy, altered myocardial microvascular structure and advanced glycation end-products (AGEs) in the pathogenesis of diabetic cardiomyopathy. We investigate...

Objective: This study was done to explore the relationship between components of metabolic syndrome and smoking. Materials and Methods: In this analytical cross-sectional study in Ahvaz, south west of Iran, the gathering data sheet was completed. Body mass index, abdominal and waist circumference, Fasting Blood sugar, Triglyceride, total cholesterol, LDL and HDL levels, systolic and diastolic ...

BACKGROUND Around birth, myocardial substrate supply changes from carbohydrates before birth to primarily fatty acids after birth. Parallel to these changes, the myocardium is expected to switch from the use of primarily lactate before birth to fatty acids thereafter. However, myocardial lactate uptake and oxidation around birth has not been measured in vivo. METHODS AND RESULTS We measured m...

Why are we not doing more to prevent sudden unexpected cardiac death? Why is prevention of the principal cause of death occurring during acute myocardial ischaemia and impending myocardial infarction ignored? The majority are caused by ventricular fibrillation. This is most common within the first hour after the onset of an acute coronary syndrome and occurs with decreasing frequency thereafter...

Assessment of myocardial viability has been a challenge for revascularisation therapeutics in determining the effectiveness of an intervention and patient prognosis. In most cases, the current standard for viability is the recovery of function measured by left ventricular (LV) wall motion and the metabolic activity measured by positron emission tomography (PET) with the uptake of the metabolic ...

The effects in vivo of physiologic increases in insulin and amino acids on myocardial amino acid balance were evaluated in conscious dogs. Arterial and coronary sinus concentrations of amino acids and coronary blood flow were measured during a 30-min basal and a 100-min experimental period employing three protocols: euglycemic insulin clamp (plasma insulin equaled 70 +/- 11 microU/ml, n = 6); e...