نتایج جستجو برای: myocardial ischaemia reperfusion injury

تعداد نتایج: 470209  

Journal: :The European respiratory journal 2009
J Sun D Yang S Li Z Xu X Wang C Bai

The present study aimed to investigate potential effects of curcumin (CUR) and dexamethasone (DXM) on ischaemia-reperfusion (I/R) induced lung injury in rats. Experimental rats were pre-treated with a single i.p. dose of vehicle, CUR (50 mg.kg(-1) or 200 mg.kg(-1)) or DXM (5 mg.kg(-1)), 2 h before anaesthesia and subjected to left lung hilus clamping with 90-min ischaemia followed by 4 h of rep...

Journal: :British Medical Bulletin 2004

Journal: :European Journal of Vascular and Endovascular Surgery 1999

2016
Sarah K Walsh Claire Y Hepburn Kathleen A Kane Cherry L Wainwright

Background and purpose: Cannabidiol (CBD) is a phytocannabinoid, with anti-apoptotic, anti-inflammatory and antioxidant effects and has recently been shown to exert a tissue sparing effect during chronic myocardial ischaemia and reperfusion (I/R). However, it is not known whether CBD is cardioprotective in the acute phase of I/R injury and the present studies tested this hypothesis. Experimenta...

Journal: :British journal of pharmacology 2010
Sarah K Walsh Claire Y Hepburn Kathleen A Kane Cherry L Wainwright

BACKGROUND AND PURPOSE Cannabidiol (CBD) is a phytocannabinoid, with anti-apoptotic, anti-inflammatory and antioxidant effects and has recently been shown to exert a tissue sparing effect during chronic myocardial ischaemia and reperfusion (I/R). However, it is not known whether CBD is cardioprotective in the acute phase of I/R injury and the present studies tested this hypothesis. EXPERIMENT...

Journal: :JPMA. The Journal of the Pakistan Medical Association 2014
Hulya Ozturk Hayrettin Ozturk Elcin Hakan Terzi Ufuk Ozgen Arif Duran Ibrahim Uygun

OBJECTIVE To investigate the potential protective effects of Rosmarinic acid (RA) on rats exposed to ischaemia/reperfusion renal injury. METHODS The prospective study was conducted at Abant Izzet Baysal University, Turkey, and comprised 21 male Spraque Dawley rats weighing 250-270g each. They were divided into three equal groups. Unilaterally nephrectomised rats were subjected to 60 minutes o...

Journal: :The European respiratory journal 2008
N Geudens M Van de Wouwer B M Vanaudenaerde R Vos C Van De Wauwer G M Verleden E Verbeken T Lerut D E M Van Raemdonck E M Conway

Ischaemia-reperfusion injury of the lung is a major cause of morbidity and mortality, particularly following lung transplantation, the mainstay treatment for patients with end-stage pulmonary disease. Effective measures to prevent this complication are lacking. Thrombomodulin (TM) is an endothelial cell receptor and cofactor for thrombin-mediated generation of the anticoagulant and anti-inflamm...

Journal: :Clinical science 1997
Y Seko Y Imai S Suzuki S Kamijukkoku K Hayasaki Y Sakomura K Tobe T Kadowaki H Maekawa N Takahashi Y Yazaki

1. Vascular endothelial growth factor, a potent angiogenic mitogen, is known to be induced in response to ischaemia as well as being secreted from tumour cells. However, the precise mechanism of vascular endothelial growth factor release in acute myocardial infarction and the effects of coronary reperfusion on the circulating levels of vascular endothelial growth factor are still unknown. 2. Ni...

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