Reduction in the Risk of Cardiovascular Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy HYZAAR is a combination of losartan (COZAAR) and hydrochlorothiazide. In patients with hypertension and left ventricular hypertrophy, losartan, often in combination with hydrochlorothiazide, reduces the risk of cardiovascular morbidity and mortality as measured by the combi...

The sedentary way of life collects victims mostly through the disorders cardiovascular system; most frequent causes are ischemic heart disease and stroke. training-induced characteristics athlete’s have well defined roles in better exercise performance at young age, prevention diseases older age. left ventricular hypertrophy age results a endurance performance, however, regular physical activit...

Case summary A 5-month-old intact female Scottish Fold cat was presented for cardiac evaluation. Careful auscultation detected a slight systolic murmur (Levine I/VI). The findings of electrocardiography, thoracic radiography, non-invasive blood pressure measurements and conventional echocardiographic studies were unremarkable. However, two-dimensional speckle tracking echocardiography revealed ...

OBJECTIVES The purpose of this paper was to determine whether microRNAs (miRNAs) involved in myocardial remodeling were differentially expressed in the blood of hypertrophic cardiomyopathy (HCM) patients, and whether circulating miRNAs correlated with the degree of left ventricular hypertrophy and fibrosis. BACKGROUND miRNAs-small, noncoding ribonucleic acids (RNAs) that regulate gene express...

BACKGROUND In hypertrophic obstructive cardiomyopathy, regional hypertrophy, myocardial replacement scarring, expanded interstitial fibrosis, and myocardial disarray can be found. The electrophysiological consequences of this substrate have not yet been investigated. Thus, the aim of this study was to assess the local electrophysiological characteristics of regional left ventricular (LV) septal...

Cardiac hypertrophy in infancy has been the subject of considerable interest for many years. An increasing number of reports have appeared in the literature describing diverse cardiac lesions in infancy, which nevertheless have similar clinical manifestations. Rosenbaum et al. incorporated this group of diseases under the heading “Primary Myocardial Disease in Infancy and Childhood.” Since most...

The role of type III transforming growth factor-β receptor (TβRIII) in the pathogenesis of heart diseases remains largely unclear. Here, we investigated the functional role and molecular mechanisms of TβRIII in the development of myocardial hypertrophy. Western blot and quantitative real time-polymerase chain reaction analyses revealed that the expression of TβRIII was significantly elevated in...

Uncoupling protein 2 (UCP2) is primarily expressed in the myocardium and is closely related to myocardial ischemia/reperfusion injury and myocardial metabolism. To explore the effects and the mechanisms of UCP2 on atorvastatin-mediated myocardium protection, the rat model of myocardial ischemia was established by ligation of the left anterior descending coronary arteries (LADs). The rats were d...

OBJECTIVES The goal of this study was to explore sex differences in myocardial remodeling in aortic stenosis (AS) by using echocardiography, cardiac magnetic resonance (CMR), and biomarkers. BACKGROUND AS is a disease of both valve and left ventricle (LV). Sex differences in LV remodeling are reported in AS and may play a role in disease phenotyping. METHODS This study was a prospective ass...

The spontaneously hypertensive rat (SHR) is a laboratory model of naturally developing hypertension and heart failure that appears to be similar in many aspects to essential hypertension in humans (Trippodo & Frohlich, 1981). Systolic blood pressure in SHR rapidly increases during 5 to 10 weeks of age and develops cardiac hypertrophy between 9 and 12 weeks of age (Shimamoto et al., 1982). Incre...