نتایج جستجو برای: myf5 genes
تعداد نتایج: 426556 فیلتر نتایج به سال:
Abstract Background Maternal nutrition during gestation affects fetal development, which has long-term programming effects on offspring postnatal growth performance. With a critical role in protein and lipid metabolism, essential fatty acids can influence the development of muscle adipose tissue. The experiment investigated late supplements (77 d prepartum), either rich saturated monounsaturate...
Mechanical forces are essential for normal adult bone function and repair, but the impact of prenatal muscle contractions on bone development remains to be explored in depth in mammalian model systems. In this study, we analyze skeletogenesis in two 'muscleless' mouse mutant models in which the formation of skeletal muscle development is disrupted; Myf5(nlacZ/nlacZ):MyoD(-/-) and Pax3(Sp/Sp) (S...
Glycosylated α-dystroglycan provides an essential link between extracellular matrix proteins, like laminin, and the cellular cytoskeleton via the dystrophin-glycoprotein complex. In secondary dystroglycanopathy muscular dystrophy, glycosylation abnormalities disrupt a complex O-mannose glycan necessary for muscle structural integrity and signaling. Fktn-deficient dystroglycanopathy mice develop...
There is increasing evidence for a positive role of Wnt signaling molecules in the activation of myogenesis in amniote embryos (Münsterberg et al., 1995; Stern et al., 1995; Capdevila et al., 1998; Tajbakhsh et al., 1998), but the mechanism of this process remains elusive. At least another molecule, Sonic hedgehog, is also required to initiate myogenesis in the presomitic mesoderm (Borycki et a...
Wnt proteins are secreted cytokines and several Wnts are expressed in the developing somites and surrounding tissues. Without proper Wnt stimulation, the organization of the dermomyotome and myotome can become defective. These Wnt signals received by somitic cells can lead to activation of Pax3/Pax7 and myogenic regulatory factors (MRFs), especially Myf5 and MyoD. However, it is currently unkno...
s of the 7th Cachexia Conference, Kobe/Osaka, Japan, December 9–11, 2013 Published online: 5 November 2013 # Springer-Verlag Berlin Heidelberg 2013 1–01 Regeneration of the rat tibialis anteriormuscle is impaired despite induction of the SPARC-beta-catenin pathway during post-immobilization recovery Lamia Slimani, Emilie Vazeille , Christiane Deval , Julien Amat, Cécile Polge, Daniel Béchet , D...
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