OBJECTIVES To evaluate associations between cumulative and peak formaldehyde exposure and mortality from acute myeloid leukemia (AML) and other lymphohematopoietic malignancies. METHODS Cox proportional hazards analyses. RESULTS Acute myeloid leukemia was unrelated to cumulative exposure. Hodgkin lymphoma relative risk estimates in the highest exposure categories of cumulative and peak expo...

INTRODUCTION Hypocellular variants of acute myeloid leukemia are very rare and almost always occur in old aged patients. In contrast, hypocellular acute lymphoblastic leukemia usually occurs in children. CASE PRESENTATION We report two Indian patients with hypocellular acute myeloid leukemia, a 32-year-old woman and a 13-year-old boy. Interestingly, one of the patients also showed bone marrow...

Blast crisis, closely resembling acute leukemia, is the usual terminal event in chronic myeloid leukemia. Using physical ("fingerprint") and cultural (colony-forming) methods, we have demonstrated distinctive patterns in the stable phase of chronic myeloid leukemia and in blast crisis. An unusual fingerprint alteration preceding the onset of the terminal phase is noted, and cell culture perturb...

Background: Decitabine (5-aza-2'-deoxycytidine, DAC) is a deoxycytidine analog currently used as an effective drug against myelodysplastic syndromes and acute myeloid leukemia. Although various studies have pointed out the epigenetic effects of this drug, its epigenetic mechanisms in different leukemic cell lines are not specified. In this lab trial study, possible epigenetic effects of decitab...

  Background and Objectives: Bone marrow necrosis (BMN) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. This study was performed to identify frequency and the underlying associated diseases of marrow necrosis. Materials and Methods: In this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the Pathology ...

Acute myeloid leukemia (AML) is the most common type of acute in adults. The incidence AML increases with age. According to Surveillance, Epidemiology, and End Results Program, over 57% new cases occur adults aged 65 years or above (65–74 years: 23.7%; 75–84 22.8%; >84 10.6%).

INTRODUCTION Therapy-related acute myeloid leukemia occurs as a complication of treatment with chemotherapy, radiotherapy, immunosuppressive agents or exposure to environmental carcinogens. CASE PRESENTATION We report a case of therapy-related acute myeloid leukemia in a 37-year-old Turkish woman in complete remission from breast cancer. Our patient presented to our facility with fatigue, fev...

Introduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase chronic myeloid leukemia. We report a case newly diagnosed patient with leukemia phase, infiltration right ovary on disease presentation. Case report. The presented abdominal pain, leukocytosis, anemia. A peripheral blood smear indicated leukemia, cytoreduc...

Background: Priapism is defined as a prolonged erection of the penis lasting over 6 hours in absence sexual stimulation. divided into two types, Low-Flow (ischemic priapism) and High-Flow (trauma). This case study aims to evaluate penile gangrene priapism sequele due Chronic Myeloid Leukemia (CML) first report Indonesia.Case Presentation: A 45-years old male patient admitted at Muara Teweh hosp...