نتایج جستجو برای: myeloid leukaemia
تعداد نتایج: 66693 فیلتر نتایج به سال:
The outlook for patients with acute myeloid leukaemia has improved in the past 30 years. Unlike other cancers, much of this progress is attributable to refinement of supportive treatment, rather than the introduction of new drugs. New antibacterial and antifungal agents, antiemetics, and improved transfusion support have decreased the rate of early death, and morbidity and mortality from alloge...
Thirty four out of 750 patients entered into the Medical Research Council's (MRC) 9th Acute Myeloid Leukaemia Trial had more than 1% basophils (range 1-27%) often with bizarre granulation and primitive forms, a rare finding in this disease. Both normal and abnormal karyotypes were present including abnormalities of 6p, 12p, and the Philadelphia chromosome. Basophilia was found in both "monoline...
The Tribbles family of proteins—comprising TRIB1, TRIB2, TRIB3 and more distantly related STK40—play important, but distinct, roles in differentiation, development oncogenesis. Of the four proteins, TRIB1 has been most well characterised structurally plays diverse cancer types. well-understood role is acute myeloid leukaemia, where it can regulate C/EBP transcription factors kinase pathways. St...
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progres...
Acute myeloid leukaemia (AML) is characterized by a block in differentiation and an unregulated proliferation of myeloid progenitor cells. While the cause of AML in children is unknown, risk factors that have been identified include exposure to toxins such as ethanol, pesticides and dietary topoisomerase II inhibitors, prior chemotherapy with alkylating agents or topoisomerase II inhibitors, co...
Myeloid sarcoma is a rare extramedullary tumour consisting of immature myeloid cells. It can arise at any anatomical location and often develops in the bowel. This report describes a case of severe acute disseminated intravascular coagulation (DIC) with multi-organ failure occurring in a 57-year-old man with chronic myelomonocytic leukaemia during bowel resection for newly diagnosed adenocarcin...
Four cases of priapism related to spinal cord trauma, myeloid leukaemia and ingestion of an indigenous drug are reported. Other causes of priapism and the management are reviewed (JPMA 33:208. 1983).
Secondary haematological changes in tuberculosis may mimic many blood dyscrasias, including leukaemia. The appearance of primitive white cells in the peripheral blood is probably more common in disseminated than in pulmonary tuberculosis (Muller, 1943; O'Brien, 1954). The reaction may involve any cell type: myeloid reactions have been reported by Marzullo and deVeer (1931) and Custer and Crocke...
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