Strains of Mycoplasma mycoides subsp. mycoides small colony (SC) type, the agent of contagious bovine pleuropneumonia (CBPP), were analysed with respect to the polymorphism of distribution of a newly discovered insertion element, IS1296, on the chromosome. Analysis of 64 strains isolated from Europe, Africa and Australia, including four vaccine strains and the type strain PG1, revealed ten diff...

Roland J. Siezen1,2,3* and Michiel Kleerebezem1,4 Top Institute Food and Nutrition (TIFN), 6700AN Wageningen, the Netherlands. Netherlands Bioinformatics Centre (NBIC), and Center for Molecular and Biomolecular Informatics (CMBI), Radboud University Nijmegen, 6500HB Nijmegen, The Netherlands. Scientific Consultant, Microbial Bioinformatics, 6711TE Ede, the Netherlands. Laboratory of Microbiolog...

Contagious bovine pleuropneumonia (CBPP) is a severe disease caused by Mycoplasma mycoides subsp. mycoides (Mmm). Knowledge on CBPP pathogenesis is fragmented and hampered by the limited availability of laboratory animal and in vitro models of investigation. The purpose of the present study is to assess respiratory explants as useful tools to study the early stages of CBPP. Explants were obtain...

F(1)F(0) ATPases have been identified in most bacteria, including mycoplasmas which have very small genomes associated with a host-dependent lifestyle. In addition to the typical operon of eight genes encoding genuine F(1)F(0) ATPase (Type 1), we identified related clusters of seven genes in many mycoplasma species. Four of the encoded proteins have predicted structures similar to the α, β, γ a...

The peculiar type of growth common to Asterococcus mycoides (Pleuropneumonia bouum), pleuropneumonia-like organisms (PPLO), and L forms of bacteria has lead to confusion and controversy. This controversy involves the interrelationships of these groups and of strains within the groups as well as their relation to bacteria in general. Excellent reviews by Sabin (1941), Elleneberger-Nobel (1951), ...