IT IS appropriate, in celebrating the great contribution which John McMichael has made to the physiological approach to medicine, to deal with a physiological subject. This paper gives a brief account of the investigations, still somewhat preliminary, which our group has been carrying out into the possible part played by bronchial muscle in airways obstruction. If increased tone of bronchial mu...

OBJECTIVE Myogenic vasoconstriction is mediated by vascular smooth muscle cells of resistance arteries sensing mechanical stretch. Angiotensin II AT1 receptors and in particular AT1BRs in murine vascular smooth muscle cells have been characterized as mechanosensors that cannot fully account for myogenic vasoconstriction observed. Therefore, we aimed at uncovering novel vascular mechanosensors b...

Aging diminishes myogenic tone in arterioles from skeletal muscle. Recent evidence indicates that both large-conductance Ca2+-activated (BKCa) and voltage-dependent (KV) K+ channels mediate negative feedback control of the myogenic response. Thus we tested the hypothesis that aging increases the contributions of KV and BKCa channels to myogenic regulation of vascular tone. Because myogenic resp...

BACKGROUND Evidence for the efficacy of therapeutic methods and procedures is being sought in accordance with the principles of Evidence Based Medicine. The choice of a physiotherapy method should be based on its documented efficacy. The purpose of the investigation was to analyse changes in functional disorders of resting muscle tone following neuromobilization treatment in patients with chron...

Muscle stiffness can reflect muscle tone, often presumed to be aberrant in persons with dysarthria. This exploratory study used the Myoton-3 to assess stiffness of the lateral tongue and mid-cheek in 10 participants with various neurologic disorders--primarily lower motor neuron (n = 6), primarily upper motor neuron (n = 4), and neurolsgically normal adults (n = 4). The Myoton delivered a 25-ms...

Earlier work with rat arteries has resulted in a widely held assumption that resistance artery smooth muscle will not contract on exposure to a reduced transplasmalemmal sodium gradient. In view of the well-recognized low sensitivity of rat tissue to cardiac glycosides, we have investigated the effects of altering the transplasmalemmal sodium gradient on vascular smooth muscle tone by using hum...

Muscle tone was tested at the shoulders and wrists of 49 randomly selected poststroke patients with the use of resting joint position (SJP and WJP), resistance to passive movement or stiffness (SRM and WRM), and angle of appearance of resistance (SAR and WAR). Subjects were tested while seated with their arm supported in a suspension sling adapted for free movement. Five of the first and immedi...

We elucidated substrates for the execution of normal gait and to understand pathophysiological mechanisms of gait failure in basal ganglia dysfunctions. In Parkinson’s disease, volitional and emotional expressions of movement processes are seriously affected in addition to the disturbance of automatic movement processes, such as adjustment of postural muscle tone and rhythmic limb mov...

[Purpose] The aim of the present study was to examine, in patients requiring prolonged mechanical ventilation, if the response of tidal volume during manually assisted breathing is dependent upon both upper extremity muscle tone and the pressure intensity of manually assisted breathing. [Subjects] We recruited 13 patients on prolonged mechanical ventilation, and assessed their upper extremity m...

Immature airways are highly compliant compared to the adult, suggesting that trachea and bronchi from immature animals may be easily compressed. Although tracheal compression has been extensively studied, the effect of transmural pressure on occlusion of immature bronchi has been neglected. The transmural pressure at which the lumen closed was determined from the transmittance of pressure along...