Continuous infusion is an attractive method of administration when muscle relaxation is needed for a longer period. The pharmacokinetic behaviour of a drug is an important determining factor for the suitability of relaxants for continuous infusion. At present mainly intermediately long acting relaxants are used for this purpose. At the end of surgery residual curarization may exist and thus ana...

There is a lack of guidelines for preoperative dosing opioid and nonopioid pain medications surgical patients, which can lead to suboptimal control. The Society Perioperative Assessment Quality Improvement identified analgesics as an area in consensus could improve patient care. aim this guideline provide that will allow perioperative physicians make optimal recommendations regarding medication...

Evidence has been presented to show that a second dose of suxamethonium is capable of producing a severe bradycardia in man. This response may be effectively prevented by the prior administration of certain non-depolarizing muscle relaxants namely tubocurarine, alcuronium, c-toxiferine and pancuronium in quantities of one-quarter or less of their muscle relaxant level. It is suggested that suxa...

Spinal muscular atrophy (SMA) is a rare lower motor neurone disease in which anesthetic management is often difficult as a result of muscle weakness, hypersensitivity to non-depolarizing neuromuscular blocking agent, and succinylcholine induced hyperkalemia. We describe a 50-year-old patient with type IV SMA for synovectomy. We decided to use an epidural technique to avoid muscle relaxants and ...

This is a report of a single-visit hypnotic cure of a woman who snored so loudly that she had to sleep in a back room at home. Her snoring recurred a year later when her orthopedist prescribed a muscle relaxant drug, and it again responded to a suggestion to "let it be impossible" to make that sound. There was no recurrence in a 4-year follow-up.