Mammary tumorigenesis in genetic crosses between the high mammary tumor incidence GR and the low incidence C57BL mouse strains is highly correlated with murine mammary tumor virus expression in milk. Although the F1 and first backcross females had a mammary tumor incidence which was consistent with a single dominant gene segregation, the tumor incidence in the critical second backcross segregan...

Background: Breast cancer is currently one of the most common types suffered by women, with highest prevalence in all countries world. Herbal plants are thought to increase immune system against tumors, which okra (Abelmoschus esculentus) has potential as an anti-tumor and anti-carcinogenic. This study aimed assess efficacy ethanol extract on granzyme expression tumor mass diameter mammary aden...

An 11-year-old spayed female Toy Poodle presented with acute tetraparesis. A small subcutaneous mass was found in the right trunk region, and magnetic resonance revealed a compressive spinal cord lesion due to an irregular bone proliferation at third cervical vertebra. After surgical resection of vertebral lesion, neurological symptoms improved, patient could walk on her own. The excised masses...

Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of Brca2 specifically in mammary epithelium development, we crossed mice bearing...

The effect of the mammotropic tumor, MtTF4, on the growth and biochemistry of the transplantable autonomous R3230AC mammary adenocarcinoma was investigated. The MtTF4 tumor, which secretes prolactin, growth hormone, and adrenocorticotropic hormone (ACTH) did not significantly alter the growth rate of the mammary tumor but did increase glucose-6-phosphate dehydrogenase (G6PD) activity in the R32...

Mammary tumors are common in cats. As mutations in human Brca2 confer an increased risk of breast cancer, the full-length cDNA of the feline homologue of Brca2 was sequenced to obtain a basis for studying the relationship between its function and susceptibility to mammary tumors. The feline Brca2 cDNA is 10 kb long, and encodes 3,371 amino acids. The amino acid sequence of feline Brca2 shares l...

The ovarian adenocarcinoma is an aggressive cancer which has the highest mortality rate of all the gynecological cancers. More than 1/3 of the patients requests medical attention for ascites and pleural effusions. The association of the triad ovarian tumor, ascites and pleural effusions raises diagnostic issues and may lead to delay of adequate treatment. We present the case of a 56 years old f...

In BALB/cfC3H and BALB/cfRIII virgin female mice, i.e., BALB/c mice carrying milk-transmitted C3H and those carrying RIII murine mammary tumor virus infection, respectively, mammary noduligenesis and tumorigenesis are remarkably different. Focal hyperplastic alveolar changes or hyperplastic alveolar nodules were removed from BALB/cfRIII or BALB/cfC3H breeding female donors and transplanted into...