Background: How residual kidney function (RKF) functions in the prevention of anemia in peritoneal dialysis (PD) patients is unclear. In this study, we investigated the association between RKF and hemoglobin (Hb) level. Methods: We performed a cross-sectional analysis of the association between RKF, defined as the mean renal creatinine and urea clearance (rCUC), and the Hb level in 50 PD patien...

OBJECTIVES To describe the epidemiology of extubation failure and identify risk factors for its occurrence in a multicenter population of neonates undergoing surgery for congenital heart disease. STUDY DESIGN We conducted a prospective observational study of neonates ≤30 days of age who underwent cardiac surgery at 7 centers within the US in 2015. Extubation failure was defined as reintubatio...

BACKGROUND Postoperative mortality has been associated with cumulative anesthetic duration below an arbitrary processed electroencephalographic threshold (bispectral index [BIS] <45). This substudy of the B-Unaware Trial tested whether cumulative duration of BIS values lower than 45, cumulative anesthetic dose, comorbidities, or intraoperative events were independently associated with postopera...

Adolescent injury victims receive care at adult trauma centers (ATCs) and pediatric trauma centers (PTCs). The purpose of this study was to identify care variations and their impact on the outcome of adolescent trauma patients treated at PTC versus ATC. We queried the Pennsylvania Trauma Systems Foundation database for trauma patients between 13 and 18 years of age from 2005 to 2010. Mortality ...

We have investigated the application of multipoint kinetic curve-fitting methods to the determination of an analyte in the presence of a single interferent. Our model system for the analyte-interferent was creatinine-acetoacetate as determined with the kinetic Jaffé method. We examined the utility of the following multipoint approaches: simultaneous equations, multivariable linear regression, a...

BACKGROUND This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery. METHODS AND RESULTS Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) treatment. Multivariable...

Propensity scores are widely used in cohort studies to improve performance of regression models when considering large numbers of covariates. Another type of summary score, the disease risk score (DRS), which estimates disease probability conditional on nonexposure, has also been suggested. However, little is known about how it compares with propensity scores. Monte Carlo simulations were condu...