Intercellular adhesion molecule 1 (ICAM-1) is a cell-surface protein overexpressed in many diseases and explored for endocytosis and transcytosis of drug delivery systems. All previous evidence demonstrating ICAM-1-mediated transport of therapeutics into or across cells was obtained using nanocarriers or conjugates coupled to multiple copies of anti-ICAM antibodies or peptides. Yet, transport o...

Alois Alzheimer, the Bavarian neuropathologist, first introduced the Alzheimer's disease (AD) in 1906 following detection of amyloid plaques, neurofibrillary tangles, and arteriosclerotic changes in the brain of his patient. AD is known as the most frequent global form of dementia, these days, representing 50-80% of all cases1 with huge patient maintenance costs (i.e. 172 billion US dollars in ...

We study the effective interaction mediated by strongly coupled Coulomb fluids between dielectric surfaces carrying quenched, random monopolar charges with equal mean and variance, both when the Coulomb fluid consists only of mobile multivalent counterions and when it consists of an asymmetric ionic mixture containing multivalent and monovalent (salt) ions in equilibrium with an aqueous bulk re...

The Front Cover shows the Multivalent Antibody-Recruiting Glycopolymers (MARGs) prepared by grafting multiple copies of dinitrophenol (DNP, pink) onto hyaluronan acid polymers (HA, cyan) for cancer immunotherapy. MARGs are able to recognize CD44 marker on cell surface and concomitantly recruit endogenous anti-DNP antibodies kill cells through immune effector functions in vitro vivo. designed co...

‎making use of a linear operator‎, ‎which is defined here by means of‎ ‎the hadamard product (or convolution)‎, ‎we define a subclass‎ ‎$mathcal {t}_{p}(a‎, ‎c‎, ‎gamma‎, ‎lambda; h)$ of meromorphically‎ ‎multivalent functions‎. ‎the main object of this paper is to‎ ‎investigate some important properties for the class‎. ‎we also derive‎ ‎many results for the hadamard roducts of functions belong...

Experimental data for the disjoining pressure of foam films stabilized by anionic surfactant in the presence of 1:1, 1:2, 1:3, and 2:2 electrolytes: NaCl, Na₂SO₄, Na₃Citrate, and MgSO₄ are reported. The disjoining pressure predicted by the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory coincides with the experimental data in the case of a 1:1 electrolyte, but it is considerably greater than the...

In this paper, we study the ratio of harmonic multivalent functions to its sequences of partial sums.

Let ᏿ * (p,α) be the class of functions f (z) which are analytic and p-valently starlike of order α in the open unit disk E. The object of the present paper is to derive an interesting condition for f (z) to be in the class ᏿ * (p,α). This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution , and reproduction in any ...

BACKGROUND Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America. Currently, no vaccine is available to prevent LB in humans, although monovalent and multivalent vaccines have been developed in the past. OBJECTIVE The aim of the current study is to conduct a systematic review and meta-analysis to evaluate and compare the findings from these two classe...