multiple sclerosis (ms) is the most common chronic autoimmune demyelinating disorder of the central nervous system (cns) which preferentially involves young women in early child bearing age. opposite to traditional view emphasized on discouraging female patients from enduring pregnancy, recent investigations showed that pregnancy-related physiological alterations, especially during the third tr...

background: fatigue, depression, and physical impairment are common  among  multiple  sclerosis (ms) patients. the aim  of  this  study was to  determine  the   relationship between depression,  physical impairment,  and  fatigue  in an iranian ms cohort. methods: fifty consecutive  relapsing-remitting ms patients and  50 age- and  sex-matched healthy  controls (hcs) were recruited  from sina r...

background: multiple sclerosis (ms) is an unpredictable neurological disease leading to severe disability in young adults.  the  majority of ms patients  use  complementary and     alternative medicine  (cam)  as adjunct  to conventional  therapies.  this study  aimed  to  investigate the prevalence  of cam utilization among  iranian patients with ms and their attitude  toward the cam usage. me...

background: the positive impacts of exercise therapy on patients’ cognitive problems still remain unknown. this study was a pilot intervention to examine the effects of combined exercise on the cognitive problems of patients with multiple sclerosis (ms) in iranian ms society over 2012 to 2013.   methods : this quasi-experimental research was carried out in the form of a pretest/posttest study. ...

background: multiple sclerosis (ms) is an autoimmune,  neuro- inflammatory disease  of  central nervous system affecting physical, emotional, and cognitive aspects of patients. association of vitamin d deficiency and ms has been shown in previous studies. the aim of this study was to evaluate serum vitamin d level in ms cases and their sex-matched healthy siblings (who are genetically near simi...

multiple sclerosis (ms) and allergy are believed to up regulate t helper cell type 1 (th1) and t helper cell type 2 (th2) responses, respectively. it has been shown that disequilibrium in the  ratio  of  th1/th2  activities may increase frequency of  one  disease and  decrease the frequency of the other. the aim of this study was to investigate the relation of ms with allergy and atopy in new d...

multiple sclerosis (ms) is an inflammatory demyelinating disease which the exact etiology is still are far to be clear. reasons for this autoimmune disease are unknown origin. the aim of present study was to evaluate serum levels of selenium in patient with ms compare to healthy subjects. a total of 46 subjects were enrolled in the study, sera of 23 ms cases and 23 healthy normal cohorts as con...

background: the effect of nutrition in the course of multiple sclerosis (ms) is a topic of great interest. the present study was aimed to evaluate the immunoglobin e (ige) against egg and fish in ms patients compared to healthy controls. methods: between march 2012 and july 2012, 48 ms patients were selected and compared with 48 healthy subjects to assess the frequency of ige against egg and fi...

multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) characterized by inflammatory and neurodegenerative processes. one of its pathophysiological hallmarks is demyelination, a consequence of oligodendroglial cell death leading supply shortfall and missing electrical insulation to axons. demyelination induced consequences on neuronal network activity and subsequen...

blood brain barrier (bbb) is a specialized non fenestrate barrier that formation by the endothelial cells and controls the transportation of the cells and molecules in to the brain. reducing in function of bbb is one of disruptions in neurological diseases like multiple sclerosis. endothelial progenitor cell (epc) help to the bbb to control the diapedesis of inflammatory cells & molecules in to...