Abstract Introduction: Multiple sclerosis is one the most common diseases of the central nervous system. Fatigue and depression are common symptoms of the disorder. The identification of the factors associated with fatigue can help to solve this problem and subsequently, reduce the problems of these patients. Objective: This study aimed to determine the predictor role of depression in...

Multiple sclerosis is a chronic inflammatory and demyelinating disorder of the CNS with an unknown aetiology. Although intrathecal immunoglobulin G (IgG) synthesis is a key feature of the disease, little is still known about the B cell response in the CNS of multiple sclerosis patients. We analysed the phenotype and kinetics of different B cell subsets in patients with multiple sclerosis, infec...

PURPOSE OF REVIEW The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. RECENT FINDINGS Genetic advances strengthen the association of multiple sclerosis with the human leukocyte antigen (HLA)-DRB1 allele and interferon-gamma polymorphisms and suggest ...

sjogren-larsson syndrome (sls) is an inherited autosomal recessive neurocutaneous disorder with congenital ichthyosis, spastic diplegia or quadriplegia and mental retardation. we report a case of sjogren-larsson syndrome with clinical profile (mental retardation, ichthyosis, spastic diplegia) and mri findings such as seen in multiple sclerosis (ms). so this rare syndrome can be another differen...

conclusions these results suggest that treadmill training and yoga practice improved ambulatory function, fatigue and mood status in the individuals with mild to moderate ms. patients and methods thirty-one ms patients, all female with mean of age of 36.75 years and expanded disability status scale scores (edss) of 1.0 to 4.0 were recruited. subjects were randomly assigned to one of the three g...

multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...

background: hormones can play a significant role in the pathogenesis of multiple sclerosis (ms). the aim of this study was to compare levels of ghrelin, leptin, and testosterone hormones of ms patients with healthy subjects, and assess the relationship between levels of peptide hormone and sex hormones in ms patients. methods: 35 ms patients with definite relapsing remitting multiple sclerosis ...

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Objective. To study the concentration of pro-inflammatory cytokine interleukin-17 in blood serum patients with multiple sclerosis.
 Materials and methods. 68 sclerosis were examined. The severity neurological deficit was assessed by EDSS MSFC. determined method enzyme-linked immunosorbent assay.
 Results. It found that sclerosis, serum, normal group as a whole, induced effect immunomo...