multiple sclerosis (ms) is characterized by multiple areas of inflammation, demyelination and neurodegeneration. infiltrating th1 cd4+ t cells secrete proinflammatory cytokines. they stimulate the release of some cytokines, expression of adhesion molecules and these cytokines may cause damage to the myelin sheath and axons. in this study, we analyzed plasma levels and gene expressions of five i...

myelin basic protein (mbp) is one of the most important constituents of the cns myelin sheaths. it is supposed that an autoimmune response directed against mbp is crucial in the demyelination process in patients with multiple sclerosis. studies have proved that free anti-mbp level in csf of ms patients is declined when the patient entered into clinical remission. some researchers evaluate the c...

multiple sclerosis (ms) is a multifactorial disease (caused by both environmental and genetic features) that could results from a demyelination of the myelin sheath. subsequently, it leads to many scars or lesions in different places within the central nervous system. the symptoms that occur depend on the site and rigorousness of the lesions and this is why people with ms experience different s...

multiple sclerosis (ms) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. extracellular matrix (ecm) have important role in the central nervous system (cns). alterations are happening to the ecm after the cns disorder like ms, alzheimer and other neural injury. tenasin-c (tnc) is a glycoprotein that is highly expressed in inflammatory conditions of the cns...

introduction: multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. melittin is one of components of bee venom and has anti-neuroinflammatory effects. curcumin also, a dietary spice from turmeric, has outstanding anti...

multiple sclerosis (ms) is an inflammatory and autoimmune disease.ms is characterized by blood brain barrier breakdown, inflammation, axonal injury, degeneration of the myelin sheath and etc. a significant association between inflammation and degeneration of neurons is observed in the brain. also active ms lesions always associated with inflammation thus inflammation is a target for treatment o...

This article is based on the ECTRIMS lecture given at the 25( th) ECTRIMS meeting which was held in Dusseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the risk/benefit ratio; (3) bridging the gap between multiple sclerosis and experimental autoimmune encephalitis; (4) promoting neuroprotection...

background: due to many physical and mental disorders that occur in multiple sclerosis patients, identifying the factors affecting coping based on the experiences of patients using qualitative study is essential to improve their quality of life. this study was conducted to explore the antecedents of coping with the disease in patients with multiple sclerosis. methods: this is a qualitative stud...