We used a PCR-based subtraction method, representational difference analysis of cDNA (cDNA--RDA), to identify genes with a higher expression in leiomyomas in comparison with the corresponding myometrium during the proliferative phase of the menstrual cycle. Increased expression of the genes for pregnancy-associated plasma protein A (PAPPA), tomoregulin, cellular retinoid acid binding protein 1 ...

Leiomyomas occur at various anatomical sites. While gastrointestinal leiomyomas are relatively uncommon, the female genital tract leiomyomas are one of the most common benign tumors. It is important to rule out the possibility of leiomyosarcoma whenever examining leiomyomas. At times this may be quite taxing as the nuclear atypia may be minimal. Not only many sections have to be submitted but a...

MEN: multiple endocrine neoplasia PEN: palisaded and encapsulated neuroma PTEN: phosphatase and tensin homolog PTHS: PTEN tumor-hamartoma syndrome M ultiple cutaneous neuromas are an uncommon finding that has been reported to occur idiopathically and in association with multiple endocrine neoplasia (MEN) 2B and phosphatase and tensin homolog (PTEN) tumorhamartoma syndrome (PTHS). Multiple cutan...

PTEN hamartoma tumor syndrome (PHTS), DICER1 syndrome, and hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome are pleiotropic tumor predisposition syndromes that include benign and malignant neoplasms affecting adults and children. PHTS includes several disorders with shared and distinct clinical features. These are associated with elevated lifetime risk of breast, thyroid, endome...

introduction : brooke-spiegler syndrome (bss) is a rare autosomal dominant disease characterized by the development of multiple adnexal cutaneous tumors such as cylindromas, trichoepitheliomas and spiradenomas. case description: a 49 years old female patient presented with a history of gradual appearance of multiple nodules situated predominantly on the scalp and face. pathologic examination of...

The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. ...

Renal leiomyomas are not uncommon mesenchymal neoplasms of the kidney, found in 5% of autopsy specimens and comprising 0.3% of all treated tumors. These tumors arise from the smooth muscle cells of the kidney and are mostly located in the renal capsule. Typical imaging features of renal leiomyomas include a peripheral location, well-defined margins, and hyperattenuation on nonenhanced computed ...

The U.S. Food and Drug Administration (FDA) is warning against the use of laparoscopic power morcellators in the majority of women undergoing myomectomy or hysterectomy for the treatment of leiomyomas because of the concern for inadvertent spread of tumor cells if an undiagnosed cancer were present. The authors, representing a 46member review group, reviewed the current literature to formulate ...