• A review on multinuclear and homonuclear multi-FID detection methods in liquids solids. These techniques allow experiment multiplexing, dramatically increasing information content, sensitivity speed. New supersequences enable elucidation of molecular structure from a single measurement. Pulse schemes with complete resonance assignment protein Applications include use multiple microcoils route...

Energetic oxetanes were first described in the 1970s, such as 3,3-bis(azidomethyl)oxetanes (BAMO) and 3-(nitratomethyl)-3-(methyl)oxetanes (NIMMO). Over past few years, hardly available only special-purpose chemicals for pharmaceutical industry. Oxetan-3-one is condensed with energetic compounds a hydrazino function amino-nitroguanidine picryl hydrazine to form Schiff bases. Hydrazinolysis of g...

Amide coupling reactions can be used to synthesize bispyridine-based ligands for use as bridging linkers in multinuclear platinum anticancer drugs. Isonicotinic acid, or its derivatives, are coupled to variable length diaminoalkane chains under an inert atmosphere in anhydrous DMF or DMSO with the use of a weak base, triethylamine, and a coupling agent, 1-propylphosphonic anhydride. The product...

Nuclear magnetic resonance (NMR) spectroscopy is a principal analytical technique used for the structure elucidation of molecules. This Primer covers different approaches to accelerate data acquisition and increase sensitivity NMR measurements through parallelization, enabled by hardware design and/or pulse sequence development. Starting with hardware-based methods, we discuss coupling multiple...

Abstract Resolving the regioselectivity of N-position on nitrogen-rich heterocycles is an important task in synthesis high energy density materials (HEDMs). In this work we developed a simple two-step route to introduce 1,2,4-triazole into 4-nitro-1,2,3-triazole N2-position, which shows excellent regioselectivity. The target compound 4-nitro-2-(1 H -1,2,4-triazol-3-yl)-1,2,3-triazole (3) was ch...