OBJECTIVES To compare structural changes in the retina seen on high-speed ultra-high-resolution optical coherence tomography (hsUHR-OCT) with multifocal electroretinography (mfERG) and automated visual fields in patients receiving hydroxychloroquine. METHODS Fifteen patients receiving hydroxychloroquine were evaluated clinically with hsUHR-OCT, mfERG, and automated visual fields. Six age-matc...

Purpose To investigate the topographic changes of the dark-adapted multifocal electroretinogram (mfERG) across adulthood in the central retina and compare the topography between macular versus extramacular, nasal versus temporal, and inferior versus superior retinal areas. Methods Sixty-five subjects (18-88 years) received a comprehensive dilated eye examination to ensure the health of their ...

PURPOSE To validate a new fiber electrode prototype for clinical electroretinography (ERG). METHODS A recently developed prototype of a disposable reference-coupled fiber electrode (patent pending Brazilian Institute of Industrial Property # PI0602186-7), including one fiber for corneal signals and a second fiber acting as reference was tested in a group of 20 healthy volunteers (17-31 years;...

PURPOSE To characterize the topographic response of the healthy human retina to acute oxygenation changes in vivo, using multifocal electroretinography (mfERG). METHODS Ten eyes in 10 subjects were examined while they breathed 21% oxygen (normoxia), 10% oxygen (hypoxia, with 90% nitrogen), or 100% oxygen (hyperoxia). Capillary oxygenation was monitored by percutaneous infrared oximetry. RES...

PURPOSE To map the distribution of cone- or rod-induced retinal responsiveness by optical imaging from macaque retina. METHODS The light reflectance changes in the posterior retina after a flash stimulus in anesthetized rhesus monkeys were measured by a modified fundus camera system equipped with a charge-coupled device (CCD) camera. The response topography of the optical signals was obtained...

PURPOSE Prolonged multifocal electroretinogram (mfERG) implicit times have been observed in diabetes, although the acute response to hyperglycemia is an acceleration of the ERG. The hypothesis for the current investigation was that this discrepancy is caused by a protracted adaptational response of the retina to hyperglycemia. METHODS Fourteen patients with type 1 diabetes without retinopathy...

PURPOSE To determine the retinal function in early age-related macular degeneration (AMD) assessed by the multifocal electroretinogram (mfERG) and flicker perimetry and to seek a relationship between local objective mfERG parameters and subjective flicker perimetry thresholds. METHODS mfERG and flicker perimetry were performed in 15 patients (15 eyes) with early AMD and 14 controls (14 eyes) ...

INTRODUCTION Our purpose was to study the correlation between the macular morphology and function in eyes with retinitis pigmentosa (RP). METHODS Sixty-six eyes from 33 patients with RP and with different visual acuity (VA) were studied using optical coherence tomography (OCT) and multifocal electroretinogram (mfERG). Correlation analysis was performed between VA, macular thickness, mfERG amp...

PURPOSE To relate in vivo microscopic retinal changes to visual function in patients who have various forms of retinal dystrophy. METHODS The UC Davis Adaptive Optics (AO) fundus camera was used to acquire in vivo retinal images at the cellular level. Visual function tests consisting of visual fields, multifocal electroretinography (mfERG), and contrast sensitivity were measured in all subjec...