Of 48 bacteria belonging to the family Enterobacteriaceae tested from urban sludge samples, one Escherichia coli isolate was resistant to colistin and possessed the resistance marker gene mcr-1 found for the first time from Bangladesh. The colistin resistant E. coli was multidrug resistant showing resistance to 11 different antibiotics tested.

Enterococcus faecalis is an opportunistic pathogen and a leading cause of nosocomial infections. Conjugative pheromone-responsive plasmids are narrow-host-range mobile genetic elements (MGEs) that are rapid disseminators of antibiotic resistance in the faecalis species. Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas and restriction-modification confer acquired and innate ...

Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...

the emergence of multidrug resistant strains of escherichia coli has complicated treatment decision and may lead to treatment failures. from april to november 2001 we prospectively evaluated the prevalence of resistance to trimethoprim-sulfamethoxazole (sxt), gentamicin, cephalothin, ciprofloxacin, and nitrofurantoin in 220 escherichia coli isolates from patients with urinary tract infections i...

results the isolates were completely resistant to the tested antibiotics, with minimum inhibitory concentration (mic) values for ceftazidime, imipenem, and gentamicin between 256 to > 256 μg/ml, 8 to > 256 μg/ml, and 64 to > 256 μg/ml, respectively. the r. dentatus extract had a broad spectrum activity against all tested isolates and maximum growth inhibition against isolates from burn wound an...

The incidence of multidrug-resistant (MDR) organisms, including methicillin-resistant Staphylococcus aureus (MRSA), is a serious threat to public health. Progress in developing new therapeutics is being outpaced by antibiotic resistance development, and alternative agents that rapidly permeabilize bacteria hold tremendous potential for treating MDR infections. A new class of glycopolymers inclu...

2-aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococc...

Introduction. Coronavirus disease 2019 is an infectious that primarily affects the lungs. Since pandemic of severe acute respiratory syndrome coronavirus 2 continues and a large number cases are registered worldwide, knowledge about virus virus-related complications growing as well. Pleural complications, pneumothorax, empyema important issues affecting better patient survival. Bacterial superi...

Clinical infections attributed to carbapenemase-producing bacteria are a pressing public health concern owing to limited therapeutic options and linked antimicrobial resistance. In recent years, studies have reported the emergence and spread of carbapenemase-producing Enterobacteriaceae and their public health impact. This has been closely followed by the global dissemination of highly resistan...

Arbekacin sulfate (ABK), an aminoglycoside antibiotic, was discovered in 1972 and was derived from dibekacin to stabilize many common aminoglycoside modifying enzymes. ABK shows broad antimicrobial activities against not only Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) but also Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, and K...