A multicomponent reaction of triazoloketones, primary amines, and 4-nitrophenyl azide was developed for the synthesis hitherto unknown angularly fused/linear bitriazoles. The two-stage mechanism well proven by isolation intermediate. This sequential consists Cornforth rearrangement triazolization, which has also been demonstrated in a one-pot manner.

Multicomponent reactions (MCRs) represent very interesting tools to reach eco-friendly and sustainable transformations in organic chemistry. In particular, the Biginelli reaction furnishes a easy approach synthesis of library biological active compounds an academic course. Here we describe realization several experiments involving potential inhibitors ?-secretase by reaction. All obtained were ...