Mucoactive agents are used to treat a variety of lung diseases involving impaired mucociliary clearance or mucus hypersecretion. The mucoactive agents studied most frequently are N-acetylcysteine (NAC), recombinant human DNase (rhDNase), and hypertonic saline. Studies on the efficacy of these have been mainly conducted in adults, and in patients with cystic fibrosis (CF). The exact role of muco...

Chronic bronchitis defies close definition, just as it has defied all attempts at prevention or cure. Its beginning is innocuous enough, being characterized by cough and clear mucoid sputum; yet this may lead to incapacitating breathlessness, heart failure and death. Pathologically the disease is disappointing in that there is no specific or diagnostic lesion, since in its early or mild stage t...

The inflammation of chronic asthma appears to be far more complex than a simple eosinophilic inflammation. All cells of the airways—inflammatory and structural—are involved and become activated including T cells, eosinophils, mast cells, macrophages, epithelial cells, fibroblasts, and even bronchial smooth muscle cells. All these cells play an eVector role by the release of pro-inflammatory med...

Bronchial asthma is a condition where the occurrence of mucus hypersecretion, narrowing airway. Symptoms bronchial apart from shortness breath accompanied by wheezing sound, sufferers also experience productive cough because sputum thick and difficult to remove. There are two simple easy therapies treat in removal airway cleaning, namely postural drainage position effective cough. The aim this ...

Mucus synthesis by the human gall bladder EDITOR,-I was interested to read the papers by Rhodes and colleagues concerning mucus synthesis by the human gall bladder, its apparent inhibition by aspirin, and other non-steroidal anti-inflammatory drugs (NSAIDs), and the suggestion that aspirin might prevent cholesterol gall stone formation by this action As gall bladder mucus glycoprotein (mucin) i...