The microsomal triglyceride transfer protein (MTP) is essential for the synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. We investigated the role the MTP -493G/T gene polymorphism in determining the apoB-100 secretion pattern and LDL heterogeneity in healthy human subjects. Groups of carriers of the T and the G variants (n = 6 each) were recruited from a cohort of hea...

Many breast tumors are hormone dependent, and there is evidence that hydrolysis of estrone sulfate (EIS) to estrone, by estrone sulfatase, is an important source of the estrogen which is found in tumors. In this study, we have developed a novel pathway for the synthesis of estrone-3-methylthiophosphonate (EI-3-MTP) and examined its ability to inhibit estrone suifatase activity in MCF-7 breast c...

HYPOTHESIS A massive transfusion protocol (MTP) decreases the use of blood components, as well as turnaround times, costs, and mortality. DESIGN Retrospective before-and-after cohort study. SETTING Academic level I urban trauma center. PATIENTS AND METHODS Blood component use was compared in 132 patients during a 2-year period following the implementation of an MTP; 46 patients who were t...

This is a retrospective review of 66 feet (mean follow-up of 3 years) in 43 patients with painful severe rheumatoid forefoot deformities. All were treated by arthrodesis of the first metatarsophalangeal (MTP) joint through a dorsomedial incision and excision of the lesser metatarsal heads through a separate plantar approach. The mean post-operative AOFAS scores were 65.94 (range: 32 to 82). The...

Background: Myofascial pain syndrome is a significant source of mechanical pain. The aim of this study was to investigate the effects of arm movement on reaction time in females with latent and active upper trapezius myofascial trigger point. Methods: In this interventional study, a convenience sample of fifteen women with one active MTP, fifteen women with one latent MTP in the upper trapez...

This paper reports an investigation on the minimal requirements for induction of the mitochondrial cyclosporin A-sensitive permeability transition pore (MTP). Energized rat liver mitochondria incubated in sucrose medium take up a Ca2+ pulse but do not show activation of the MTP upon addition of fully uncoupling concentrations of carbonyl cyanide-p-trifluoromethoxyphenyl hydrazone (FCCP). Yet, a...

Historically CYP1A1 protein is known to be located in the endoplasmic reticulum (ER; microsomes). More recently, CYP1A1 was shown to be targeted to the inner mitochondrial membrane; mitochondrial import is dependent on NH2-terminal processing that exposes a cryptic targeting signal. Intriguingly, microsomal and mitochondrial CYP1A1 enzymes exhibit different substrate specificities, electron don...

Vasculature is an important component of the neural stem cell niche in brain. It regulates neural stem/progenitor (NS/P) cell self-renewal, differentiation, and migration. In the neurogenic niches of adult brain, NS/P cells lie close to blood vessels, and proliferating NS/P cells frequently contact the vasculature. In the present study we showed that NS/P cells in co-culture with brain endothel...

Background: Metoprolol (MTP) with its low biodegradability is one of the most dominant micropollutant in the effluent of wastewater treatment plants. The aim of this study was to investigate the removal of metoprolol from aqueous solutions by the activated carbon prepared from pine cones. Methods: The pine cones were activated using thermal activation method. Characteristics of the adsorbent w...

Successful deformity correction utilizing first metatarsophalangeal (MTP) fusion for hallux valgus with concomitant degenerative changes of the MTP joint is well documented. Currently, there limited discussion in literature focusing on triplanar arthrodesis. Presented a novel approach triplane and biplanar locked plating system.