We showed previously that diploid human fibroblasts that express a transfected HRAS oncogene from the human bladder carcinoma cell line T24 exhibit several characteristics of transformed cells but do not acquire an infinite life-span and are not tumorigenic. To extend these studies of the T24 HRAS in human cells, we have utilized an infinite life-span, but otherwise phenotypically normal, human...

BACKGROUND It is currently unknown whether bone erosion in gout occurs through an 'inside-out' mechanism due to direct intra-osseous crystal deposition or through an 'outside-in' mechanism from the surface of bone. The aim of this study was to examine the mechanism ('outside-in' vs. 'inside-out') of monosodium urate (MSU) crystal deposition in bone erosion in gout. Specifically, we used three-d...

NuShellX is a set of computer codes written by Bill Rae [1] that are used to obtain exact energies, eigenvectors and spectrosopic overlaps for low-lying states in shellmodel Hamiltonian matrix calculations with very large basis dimensions It uses a J-coupled proton-neutron basis, and J-scheme matrix dimensions of up to the order of 100 million can be considered. NuShellX@MSU is a set of wrapper...

The universal formula for the minimal required energy in optical resonators of the antennae attaining resolution at the level of the standard quantum limit is obtained (see Appendix A). The complete analysis of a new topology of interferometric gravitational wave antenna is presented. This new scheme is based on princilples of quantum intracavity measurements of crossquadrature observable and u...

BACKGROUND Gout is considered one of the most painful acute conditions caused by deposition of monosodium urate (MSU) crystals within joints. Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). However, the molecular mechanisms of the regulation remain unclear. METHODS A miRNA microa...

The Microwave Sounding Unit (MSU) onboard the National Oceanic and Atmospheric Administration polar-orbiting satellites measures the atmospheric temperature from the surface to the lower stratosphere under all weather conditions, excluding precipitation. Although designed primarily for monitoring weather processes, the MSU observations have been extensively used for detecting climate trends, an...

The results of cultures carried out on urine collected by a midstream technique (MSU) have been compared with the results of cultures of urine collected by suprapubic bladder aspiration (SPA) in the same 903 patients. Comparisons indicate that when there are more than 100 x 10(6)/l (100 000/ml) Gram-negative bacteria in the midstream urine this finding is confirmed by suprapubic aspiration in 9...

OBJECTIVES To establish the usefulness of ultrasonography (US) for diagnosing gout and to determine whether there are sonographic features that are characteristic for gout but not for other arthropathies. METHODS We retrospectively compared joint images of gout patients with matching images from patients with other rheumatic conditions. Images of 37 joints of 23 patients with monosodium urate...

Events like hurricanes, earthquakes, or accidents can impact a large number of people. Not only are people in the immediate vicinity of the event affected, but concerns about their well-being are shared by the local government and well-wishers across the world. The latest information about news events could be of use to government and aid agencies in order to make informed decisions on providin...