Failure of chemotherapy associated with expression of the multidrug resistance protein p170 frequently occurs in retinoblastoma (RB). Despite using cyclosporine, which inhibits p170 and improves our chemotherapy results, rare failures occur. In nonmetastatic primarily enucleated RBs, we show expression ofpl7O in 3 of 18 samples and expression of multidrug resistance protein (MRP), the second pr...

Multimedia database systems (MMDBSs) have to be capable to handle efficiently time-dependent and timeindependent data, and to support Quality-of-Service (QoS). To support continuous playout of time-dependent data, reservations of the limited resources disk I/O bandwidth and network bandwidth have to be combined with appropriate buffer management. Based on the special requirements of the DEDICAT...

To assess the effect of food form (FF) on postprandial (PP) plasma amino acid (AA) concentrations, ten older adults (five men and five women, age 72 (SEM 2) years, BMI 26·0 (SEM 0·9) kg/m) consumed, on separate days, energy and macronutrient-matched test meal replacement products (MRP) (approximately 25 % of the subject’s daily energy need; approximately 54 % carbohydrate, 21 % protein, 25 % fa...

BACKGROUND Exposure to tenofovir disoproxil fumarate (TDF) may cause renal toxicity. Inhibitors of TDF's apical multidrug-resistance-associated protein efflux-transporters (MRPs) in the renal proximal tubule could enhance this unwanted effect. METHODS We performed a cohort study involving patients with human immunodeficiency virus type 1 (HIV) infection. All patients had a suppressed viral lo...

A cDNA encoding the novel drug resistance gene, LRP (originally termed lung resistance-related protein), was isolated from HT1080/DR4, a 220-fold doxorubicin-resistant human fibrosarcoma cell line which displays a multidrug resistance phenotype and overexpresses the multidrug resistance protein (MRP) but does not overexpress P-glycoprotein encoded by the MDR1 gene. Using the full-length 2.8-kb ...

OBJECTIVE Diagnosing tumor progression and pseudoprogression remains challenging for many clinicians. Accurate recognition of these findings remains paramount given necessity of prompt treatment. However, no consensus has been reached on the optimal technique to discriminate tumor progression. We sought to investigate the role of magnetic resonance perfusion (MRP) to evaluate tumor progression ...

The paper exploits distributed object technology to develop an enterprise application that integrates material requirement planning (MRP) with job shop simulator. The application aims to realize an integrated system that has rapid response to changing requirements and capability to integrate heterogeneous manufacturing facilities. At first, the application accepts the customer’s order and perfo...

Retinoids are important regulators of epithelial differentiation. AGN 193109 is a high-affinity antagonist and inverse agonist for the nuclear retinoic acid receptors (RARs). Paradoxically, both AGN 193109 and retinoid agonists inhibit the expression of the differentiation marker MRP-8 in normal human keratinocytes (NHKs). TTNPB, an RAR agonist, and AGN 193109 mutually antagonize MRP-8 inhibiti...

This is a paper in mathematics, specifically in set theory. On the example of the measure recognition problem (MRP), the paper highlights the phenomenon of the utility of a multidisciplinary mathematical approach to a single mathematical problem, in particular, the value of a set-theoretic analysis. MRP asks if for a given Boolean algebra, B, and a property, Phi, of measures, one can recognize ...